Mitochondrial genome transfer drives metabolic reprogramming in adjacent colonic epithelial cells promoting TGFβ1-mediated tumor progression

Abstract Although nontumor components play an essential role in colon cancer (CC) progression, the intercellular communication between CC cells and adjacent colonic epithelial cells (CECs) remains poorly understood. Here, we show that intact mitochondrial genome (mitochondrial DNA, mtDNA) is enriche...

Full description

Bibliographic Details
Published in:	Nature Communications
Main Authors:	Bingjie Guan, Youdong Liu, Bowen Xie, Senlin Zhao, Abudushalamu Yalikun, Weiwei Chen, Menghua Zhou, Qi Gu, Dongwang Yan
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-04-01
Online Access:	https://doi.org/10.1038/s41467-024-48100-y

Similar Items

Tumour‐associated macrophage‐derived DOCK7‐enriched extracellular vesicles drive tumour metastasis in colorectal cancer via the RAC1/ABCA1 axis
by: Weiwei Chen, et al.
Published: (2024-02-01)

Metabolic Reprogramming of Mammary Epithelial Cells during TGF-β-Induced Epithelial-to-Mesenchymal Transition
by: Wan Hua, et al.
Published: (2021-09-01)

Association between serum iron status and the risk of colorectal cancer in US adults: a cross-sectional analysis of NHANES 2001–2020
by: Menghua Zhou, et al.
Published: (2024-12-01)

SETD2 loss in renal epithelial cells drives epithelial‐to‐mesenchymal transition in a TGF‐β‐independent manner
by: Tianchu Wang, et al.
Published: (2024-01-01)

TGF-β signaling pathway in induced pluripotent stem cells reprogramming
by: Weiwen Fan, et al.
Published: (2024-09-01)

Integrative analysis of mitochondrial metabolic reprogramming in early-stage colon and liver cancer
by: Yeongmin Kim, et al.
Published: (2023-08-01)

MTA1, a Novel ATP Synthase Complex Modulator, Enhances Colon Cancer Liver Metastasis by Driving Mitochondrial Metabolism Reprogramming
by: Ting Wang, et al.
Published: (2023-09-01)

Interferon signaling drives epithelial metabolic reprogramming to promote secondary bacterial infection.
by: Grace P Carreno-Florez, et al.
Published: (2023-11-01)

Interferon signaling drives epithelial metabolic reprogramming to promote secondary bacterial infection
by: Grace P. Carreno-Florez, et al.
Published: (2023-11-01)

TGFβ inhibition and mesenchymal to epithelial transition initiation by Xenopus egg extract: first steps towards early reprogramming in fish somatic cell
by: Nathalie Chênais, et al.
Published: (2023-06-01)

Tumor cell metabolic reprogramming and hypoxic immunosuppression: driving carcinogenesis to metastatic colonization
by: Theodora Katopodi, et al.
Published: (2024-01-01)

Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism
by: Claudio Bussi, et al.
Published: (2022-11-01)

Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features
by: Dustin J. Flanagan, et al.
Published: (2022-12-01)

Epithelial disruption drives mesendoderm differentiation in human pluripotent stem cells by enabling TGF-β protein sensing
by: Thomas Legier, et al.
Published: (2023-01-01)

Cellular crosstalk mediated by TGF-β drives epithelial-mesenchymal transition in patient-derived multi-compartment biliary organoids
by: Hiroaki Ayabe, et al.
Published: (2025-07-01)

Metabolic Reprogramming and Longevity of Tissue-Resident Memory T Cells
by: Youdong Pan, et al.
Published: (2018-06-01)

Effect of aging on the formation and growth of colonic epithelial organoids by changes in cell cycle arrest through TGF-β-Smad3 signaling
by: Min Kyoung Jo, et al.
Published: (2023-07-01)

Modeling TGF-β signaling pathway in epithelial-mesenchymal transition
by: Pasquale Laise, et al.
Published: (2012-03-01)

Correlation of Expression of TGF- β and MMP2 between Prostatic Adenocarcinoma and Adjacent Unaffected Parenchyma
by: Silvija Mašić, et al.
Published: (2022-01-01)

Colonic stem cells from normal tissues adjacent to tumor drive inflammation and fibrosis in colorectal cancer
by: Yuanyuan Zhao, et al.
Published: (2023-08-01)

Changes in epithelial cells adjacent to orthodontic devices
by: Zena Hekmat Altaee, et al.
Published: (2024-10-01)

Berberine suppressed the epithelial–mesenchymal transition (EMT) of colon epithelial cells through the TGF-β1/Smad and NF-κB pathways associated with miRNA-1269a
by: chao Huang, et al.
Published: (2024-08-01)

Biphasic Role of Tgf-β Signaling during Müller Glia Reprogramming and Retinal Regeneration in Zebrafish
by: Poonam Sharma, et al.
Published: (2020-02-01)

TGF-β1 Induces EMT in Bovine Mammary Epithelial Cells Through the TGFβ1/Smad Signaling Pathway
by: Qing Chen, et al.
Published: (2017-08-01)

Role of glycosylation in TGF-β signaling and epithelial-to-mesenchymal transition in cancer
by: Jing Zhang, et al.
Published: (2020-06-01)

Oxoglutarate dehydrogenase-L regulates mitochondrial metabolism reprogramming of renal tubular epithelial cells to alleviate renal fibrosis
by: YANG Yingxian, et al.
Published: (2025-06-01)

Epithelial NAD+ depletion drives mitochondrial dysfunction and contributes to intestinal inflammation
by: Elizabeth A. Novak, et al.
Published: (2023-09-01)

ADAMTS16 drives epithelial-mesenchymal transition and metastasis through a feedback loop upon TGF-β1 activation in lung adenocarcinoma
by: Lingyan Xiao, et al.
Published: (2024-11-01)

Effects of PPARγ ligands on TGF-β1-induced epithelial-mesenchymal transition in alveolar epithelial cells
by: Dagher Hayat, et al.
Published: (2010-02-01)

Myricetin suppresses TGF-β-induced epithelial-to-mesenchymal transition in ovarian cancer
by: Hui-Wen Yang, et al.
Published: (2023-11-01)

Network motifs and hypermotifs in TGFβ-induced epithelial to mesenchymal transition and metastasis
by: Gottumukkala Sai Bhavani, et al.
Published: (2023-03-01)

Cold snare polypectomy for polyp adjacent to colonic diverticulum
by: Yoko Kubosawa, MD, et al.
Published: (2018-03-01)

MRPL12 K163 acetylation inhibits ccRCC via driving mitochondrial metabolic reprogramming
by: Xingzhao Ji, et al.
Published: (2025-08-01)

Mitochondrial Dynamics: In Cell Reprogramming as It Is in Cancer
by: Javier Prieto, et al.
Published: (2017-01-01)

Human alveolar epithelial cells type II are capable of TGFβ-dependent epithelial-mesenchymal-transition and collagen-synthesis
by: Torsten Goldmann, et al.
Published: (2018-07-01)

Structural Modification and Optimisation of Hyperoside Oriented to Inhibit TGF-β-Induced EMT Activity in Alveolar Epithelial Cells
by: Ziye Gao, et al.
Published: (2024-05-01)

Angiotensin II Alters Mitochondrial Membrane Potential and Lipid Metabolism in Rat Colonic Epithelial Cells
by: Darby D. Toth, et al.
Published: (2024-08-01)

Metformin Improves Epithelial-to-Mesenchymal Transition Induced by TGF-β1 in Renal Tubular Epithelial NRK-52E Cells via Inhibiting Egr-1
by: Meiping Guan, et al.
Published: (2018-01-01)

Effects of TGF-β3 on meniscus repair using human amniotic epithelial cells
by: Yupeng He, et al.
Published: (2025-03-01)

Skullcapflavone II suppresses TGF-β-induced corneal epithelial mesenchymal transition in vitro
by: Meng-Xi Li, et al.
Published: (2025-02-01)