Effects of Isoxazolyl Steroids on Key Genes of Sonic Hedgehog Cascade Expression in Tumor Cells

Activation of the Hedgehog (Hh) signaling pathway is often associated with the progression of various types of cancer. The purpose of study was to search for inhibitors of the Hh signaling pathway among eight compounds belonging to the group of isoxazolyl steroids. The evaluation of the effectivenes...

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:	Molecules
المؤلفون الرئيسيون:	Anna Aleksandrova, Arif Mekhtiev, Olga Timoshenko, Elena Kugaevskaya, Tatiana Gureeva, Alisa Gisina, Maria Zavialova, Kirill Scherbakov, Anton Rudovich, Vladimir Zhabinskii, Vladimir Khripach
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	MDPI AG 2024-08-01
الموضوعات:	steroids isoxazoles Hh receptors cancer cell proliferation MMP
الوصول للمادة أونلاين:	https://www.mdpi.com/1420-3049/29/17/4026

مواد مشابهة

Association of Sonic Hedgehog with the extracellular matrix requires its zinc-coordination center
حسب: Carina Jägers, وآخرون
منشور في: (2021-04-01)

Molecular Mechanisms Involving the Sonic Hedgehog Pathway in Lung Cancer Therapy: Recent Advances
حسب: Chao Ma, وآخرون
منشور في: (2022-04-01)

Combined experimental and theoretical studies of regio- and stereoselectivity in reactions of β-isoxazolyl- and β-imidazolyl enamines with nitrile oxides
حسب: Ilya V. Efimov, وآخرون
منشور في: (2016-11-01)

Stromal hedgehog signaling maintains smooth muscle and hampers micro-invasive prostate cancer
حسب: Zhaohui Yang, وآخرون
منشور في: (2017-01-01)

Isoxazolyl-Derived 1,4-Dihydroazolo[5,1-<i>c</i>][1,2,4]Triazines: Synthesis and Photochemical Properties
حسب: Elena V. Sadchikova, وآخرون
منشور في: (2023-04-01)

European Hedgehogs as Hosts of Chaphamaparvovirus, Italy
حسب: Federica Di Profio, وآخرون
منشور في: (2024-12-01)

Hand hygiene practices among healthcare workers – An audit conducted in a tertiary care hospital in the central province of Sri Lanka
حسب: I. K. Jayasinghe, وآخرون
منشور في: (2022-08-01)

Synthesis of Fused Isoxazoles: A Comprehensive Review
حسب: Niveditha N. Mallik, وآخرون
منشور في: (2024-01-01)

Implementation of the Hand hygiene self-assessment framework in a primary healthcare Centre in Saudi Arabia: A follow-up study
حسب: Olaa M. Alharbi, وآخرون
منشور في: (2025-03-01)

Structure and Biological Activity of Ergostane-Type Steroids from Fungi
حسب: Vladimir N. Zhabinskii, وآخرون
منشور في: (2022-03-01)

The value of the hedgehog signal in osteoblasts in fluoride-induced bone-tissue injury
حسب: Chaonan Deng, وآخرون
منشور في: (2021-02-01)

Hedgehog Pathway Inhibitors against Tumor Microenvironment
حسب: Silpa Gampala, وآخرون
منشور في: (2021-11-01)

Helmholtz operators on infinite graphs
حسب: Varadha Raj Manivannan, وآخرون
منشور في: (2024-01-01)

The design, synthesis and antiplasmodial evaluation of novel sulfoximine-isoxazole hybrids as potential antimalarial agents
حسب: Jackie L. Mabasa, وآخرون
منشور في: (2024-04-01)

Syntheses and crystal structures of a nitro–anthracene–isoxazole and its oxidation product
حسب: Chun Li, وآخرون
منشور في: (2022-07-01)

The Hedgehog signal transducer Smoothened and microRNA-326: pathogenesis and regulation of drug resistance in pediatric B-cell acute lymphoblastic leukemia
حسب: Sheybani Z, وآخرون
منشور في: (2019-08-01)

Synthesis and radical oxidation of steroidal 1-oxo-5α-alcohols
حسب: Vladimir A. Khripach, وآخرون
منشور في: (2008-02-01)

A Joint Less Ordinary: Intriguing Roles for Hedgehog Signalling in the Development of the Temporomandibular Synovial Joint
حسب: Malgorzata Kubiak, وآخرون
منشور في: (2016-08-01)

Hole-Hole Collective Excitations in 106, 112, 130Sn Isotopes
حسب: Fahima A. Saber, وآخرون
منشور في: (2023-06-01)

BMP and Hedgehog Regulate Distinct AGM Hematopoietic Stem Cells Ex Vivo
حسب: Mihaela Crisan, وآخرون
منشور في: (2016-03-01)

Expression of Hedgehog Signaling Pathway Proteins in Basal Cell Carcinoma: Clinicopathologic Study
حسب: Deng LJ, وآخرون
منشور في: (2022-11-01)

A hedgehog-like signal is involved in slow muscle differentation in Sepia officinalis
حسب: A Grimaldi, وآخرون
منشور في: (2007-01-01)

The H2Valdien derivatives regulate the epithelial–mesenchymal transition of hepatoma carcinoma cells through the Hedgehog signaling pathway
حسب: Zhao Xuhui, وآخرون
منشور في: (2024-06-01)

Direct ring fluorination of 3-substituted 5-(1,3-dioxane) acetal isoxazoles: application to the formal synthesis of a bioactive fluorinated isoxazole
حسب: Bacheley, Lucas, وآخرون
منشور في: (2024-02-01)

Butylated hydroxytoluene (BHT) induces zebrafish spinal cord defects and scoliosis by inhibiting the hedgehog pathway
حسب: Hao Cheng, وآخرون
منشور في: (2025-08-01)

A Facile Approach to Bis(isoxazoles), Promising Ligands of the AMPA Receptor
حسب: Dmitry A. Vasilenko, وآخرون
منشور في: (2021-10-01)

Targeting the hedgehog pathway in MET mutation cancers and its effects on cells associated with cancer development
حسب: Yifan Du, وآخرون
منشور في: (2023-11-01)

Quinine Esters with 1,2-Azole, Pyridine and Adamantane Fragments
حسب: Gulim K. Mukusheva, وآخرون
منشور في: (2022-05-01)

Hedgehog signaling regulates osteoblast differentiation in zebrafish larvae through modulation of autophagy
حسب: Zhanying Hu, وآخرون
منشور في: (2019-05-01)

Hedgehog and PI3K/Akt/mTOR Signaling Pathways Involvement in Leukemic Malignancies: Crosstalk and Role in Cell Death
حسب: Mariaconcetta Sicurella, وآخرون
منشور في: (2025-02-01)

A Note on Estimating the Importance of Interactions among Economic Entities
حسب: Emilian Dobrescu
منشور في: (2019-08-01)

Signaling Switching from Hedgehog-GLI to MAPK Signaling Potentially Serves as a Compensatory Mechanism in Melanoma Cell Lines Resistant to GANT-61
حسب: Nikolina Piteša, وآخرون
منشور في: (2023-05-01)

5-Chloroisoxazoles: A Versatile Starting Material for the Preparation of Amides, Anhydrides, Esters, and Thioesters of 2<i>H</i>-Azirine-2-carboxylic Acids
حسب: Anastasiya V. Agafonova, وآخرون
منشور في: (2022-12-01)

Synthesis and Antimicrobial Evaluation of Some Heterocyclic Chalcone Derivatives
حسب: Essam Mohamed Sharshira, وآخرون
منشور في: (2011-03-01)

Synthesis of Some Fused Pyrazoles and Isoxazoles
حسب: Dandu Bhaskar Reddy, وآخرون
منشور في: (2000-12-01)

Anthracen-9-ylmethylene-(3,4-dimethylisoxazol-5-yl)amine
حسب: Abdullah M. Asiri, وآخرون
منشور في: (2011-09-01)

β-arrestin1-mediated acetylation of Gli1 regulates Hedgehog/Gli signaling and modulates self-renewal of SHH medulloblastoma cancer stem cells
حسب: Evelina Miele, وآخرون
منشور في: (2017-07-01)

Molecular characteristics and cancer immunity of LRP1B and its relationship with the Hedgehog signaling pathway in colorectal cancer
حسب: Yuan Liu, وآخرون
منشور في: (2025-03-01)

Intake, evaluation of small ruminant nutrition system model and prediction of body composition of Santa Ines lambs fed diets with different levels of energy
حسب: Iana Sérvulo Gomes Maia, وآخرون
منشور في: (2014-09-01)

Hyperinsulinemic hypoglycemia in adolescents: case report and systematic review
حسب: M. G. Castillo-López, وآخرون
منشور في: (2022-03-01)