Apocrine secretion by the choroid plexus

Abstract The choroid plexus (ChP) epithelium secretes cerebrospinal fluid (CSF) and signaling factors that influence brain development. In addition to classical secretory pathways, the ChP also employs apocrine secretion, in which large cytoplasmic portions bud from the apical surface in structures...

Full description

Bibliographic Details
Published in:	Fluids and Barriers of the CNS
Main Authors:	Ya’el Courtney, Maria K. Lehtinen
Format:	Article
Language:	English
Published:	BMC 2025-07-01
Subjects:	Apocrine secretion Choroid plexus Cerebrospinal fluid Epithelial cells Exocytosis Calcium
Online Access:	https://doi.org/10.1186/s12987-025-00684-3

Similar Items

Transporters, Ion Channels, and Junctional Proteins in Choroid Plexus Epithelial Cells
by: Masaki Ueno, et al.
Published: (2024-03-01)

Breakthroughs in choroid plexus and CSF biology from the first European Choroid plexus Scientific Forum (ECSF)
by: Laura Pellegrini, et al.
Published: (2024-05-01)

Targeting choroid plexus epithelium as a novel therapeutic strategy for hydrocephalus
by: Yijian Yang, et al.
Published: (2022-06-01)

Association between choroid plexus volume and cognitive function in community-dwelling older adults without dementia: a population-based cross-sectional analysis
by: Yosuke Hidaka, et al.
Published: (2024-12-01)

Hypoxemia exerts detrimental effects on the choroid plexuses and cerebrospinal fluid system in rats
by: Rawan Barakat, et al.
Published: (2025-03-01)

Aging alters the expression of trophic factors and tight junction proteins in the mouse choroid plexus
by: Jayanarayanan Sadanandan, et al.
Published: (2024-09-01)

The influence of the choroid plexus on brain function: beyond its role in cerebrospinal fluid production
by: Sayako Katada, et al.
Published: (2025-07-01)

Murine MPDZ‐linked hydrocephalus is caused by hyperpermeability of the choroid plexus
by: Junning Yang, et al.
Published: (2018-12-01)

The choroid plexuses and their impact on developmental neurogenesis.
by: Pia Annette Johansson
Published: (2014-10-01)

Genetic disruption of slc4a10 alters the capacity for cellular metabolism and vectorial ion transport in the choroid plexus epithelium
by: Inga Baasch Christensen, et al.
Published: (2020-01-01)

Cycle-dependent sex differences in expression of membrane proteins involved in cerebrospinal fluid secretion at rat choroid plexus
by: Ida Marchen Egerod Israelsen, et al.
Published: (2023-11-01)

The path from the choroid plexus to the subventricular zone: go with the flow!
by: Ana Mendanha Falcao, et al.
Published: (2012-08-01)

Morphological changes of the choroid plexus in the lateral ventricle across the lifespan: 5551 subjects from fetus to elderly
by: Jiaxin Li, et al.
Published: (2025-09-01)

Age-appropriate potassium clearance from perinatal cerebrospinal fluid depends on choroid plexus NKCC1
by: Ryann M. Fame, et al.
Published: (2023-06-01)

The choroid plexus in health and in disease: dialogues into and out of the brain
by: Fernanda Marques, et al.
Published: (2017-11-01)

Multimodal MRI reveals impaired glymphatic function with choroid plexus enlargement and cerebrospinal fluid expansion in alzheimer’s disease
by: Weiqi Lin, et al.
Published: (2025-08-01)

Hypercholesterolemia negatively influences morphology and molecular markers of epithelial cells within the choroid plexus in rabbits
by: Fumiko Obata, et al.
Published: (2020-02-01)

Deep learning segmentation of the choroid plexus from structural magnetic resonance imaging (MRI): validation and normative ranges across the adult lifespan
by: Jarrod J. Eisma, et al.
Published: (2024-02-01)

Associations between the choroid plexus and tau in Alzheimer’s disease using an active learning segmentation pipeline
by: Jiaxin Li, et al.
Published: (2024-07-01)

Atypical choroid plexus papilloma: A case report
by: Yanyan Chen, et al.
Published: (2022-01-01)

Choroid plexus carcinoma in adults: an extremely rare case
by: Selcuk Ozdogan, et al.
Published: (2015-03-01)

Distribution of Monocarboxylate Transporters in Brain and Choroid Plexus Epithelium
by: Masaki Ueno, et al.
Published: (2023-07-01)

A volumetric study of the choroid plexus in neuropsychiatric systemic lupus erythematosus
by: Hu Liu, et al.
Published: (2025-01-01)

Choroid plexus and the blood–cerebrospinal fluid barrier in disease
by: Peter Solár, et al.
Published: (2020-05-01)

Methods to extract and analyze fluid from human pluripotent stem cell-derived choroid plexus organoids
by: Leon H. Chew, et al.
Published: (2024-01-01)

The choroid plexus as a site of damage in hemorrhagic and ischemic stroke and its role in responding to injury
by: Jianming Xiang, et al.
Published: (2017-03-01)

Region-informed machine learning model for choroid plexus segmentation in Alzheimer’s disease
by: Liangdong Zhou, et al.
Published: (2025-07-01)

Inflammatory changes in the choroid plexus following subarachnoid hemorrhage: the role of innate immune receptors and inflammatory molecules
by: Peter Solár, et al.
Published: (2025-01-01)

NH4Cl-induced metabolic acidosis increases the abundance of HCO3− transporters in the choroid plexus of mice
by: Laura Øllegaard Johnsen, et al.
Published: (2024-10-01)

Choroid Plexus in Alzheimer’s Disease—The Current State of Knowledge
by: Tiago Gião, et al.
Published: (2022-01-01)

Altered secretory and neuroprotective function of the choroid plexus in progressive multiple sclerosis
by: Sabela Rodríguez-Lorenzo, et al.
Published: (2020-03-01)

A case of apocrine cystadenoma
by: Juan CHENG, et al.
Published: (2024-01-01)

Clinical Features and Prognostic Risk Factors of Choroid Plexus Tumors in Children
by: Wen-Jian-Long Zhou, et al.
Published: (2018-01-01)

Papillomas and carcinomas of the choroid plexus: histological and immunohistochemical studies and comparison with normal fetal choroid plexus
by: Ana Silvia Carvalho de Menezes Barreto, et al.
Published: (2004-09-01)

Engineering choroid plexus-on-a-chip with oscillatory flow for modeling brain metastasis
by: Jungeun Lim, et al.
Published: (2023-10-01)

Influx mechanisms in the embryonic and adult rat choroid plexus: a transcriptome study
by: Norman Ruthven Saunders
Published: (2015-04-01)

Aquaporin-1 and Aquaporin-4 Expression in Ependyma, Choroid Plexus and Surrounding Transition Zones in the Human Brain
by: Ronja Bihlmaier, et al.
Published: (2023-01-01)

Synchronous supratentorial and infratentorial choroid plexus papilloma: case report and review of the literature
by: Akshay V. Kulkarni, et al.
Published: (2025-02-01)

Transport of thyroid hormones via the choroid plexus into the brain: the roles of transthyretin and thyroid hormone transporters
by: Samantha J. Richardson, et al.
Published: (2015-03-01)

Choroid Plexus Xanthogranuloma: Is it an Incidental Finding?
by: Selin Yetkinel, et al.
Published: (2016-12-01)