NAFLD Aggravates Septic Shock Due to Inadequate Adrenal Response and 11β-HSDs Dysregulation in Rats

• 出版年: Pharmaceutics
• 主要な著者: Hui-Chun Huang, Ming-Hung Tsai, Fa-Yauh Lee, Te-Yueh Lin, Ching-Chih Chang, Chiao-Lin Chuang, Shao-Jung Hsu, Ming-Chih Hou, Yi-Hsiang Huang
• フォーマット: 論文
• 言語: 英語
• 出版事項: MDPI AG 2020-04-01
• 主題: non-alcoholic fatty liver disease; adrenal function; 11β-HSD1; shock
• オンライン･アクセス: https://www.mdpi.com/1999-4923/12/5/403

Background: Non-alcoholic fatty liver disease (NAFLD) is linked with metabolic syndrome. Previous studies showed that obesity may disrupt adrenal function and adversely affect its counter-regulations against shock. This study hence evaluated adrenal function abnormalities in NAFLD with shock. Methods: Sprague-Dawley rats were fed with regular chow-diet (control) or high fat diet (HFD, 60% energy derived from fat). Blood tests were performed at the end of the 4th, 6th and 8th week, respectively. Experiments were performed at the end of the 8th week. Results: HFD rats developed NAFLD. HFD rats had 27% and 51% increase in plasma corticosterone at the 6th and 8th week in usual status. However, HFD rats had 5 times more reduction of mean arterial pressure in response to lipopolysaccharide-induced sepsis as compared to control rats. The corticosterone increment ratio was also lower in HFD rats, even after ACTH administration. 11β-HSD system tended to generate more corticosterone in HFD rats under hemodynamic stable status without shock and the trend was lost in HFD rats with septic shock. Conclusion: Rats with NAFLD had profound septic shock due to inadequate corticosterone response. This is, at least partly, due to 11β-HSDs dysregulation in sepsis.