Histone deacetylases facilitate the accurate repair of broken forks

We have recently uncovered that loss of the yeast histone deacetylases Rpd3 (Reduced Potassium Dependency 3) and Hda1 (Histone DeAcetylase 3) affects the cohesion between sister chromatids thus impairing repair of DNA damage at replication forks and enhancing genetic instability. Here we discuss the...

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Bibliographic Details
Published in:Molecular & Cellular Oncology
Main Authors: Belén Gómez-González, Pedro Ortega, Andrés Aguilera
Format: Article
Language:English
Published: Taylor & Francis Group 2020-03-01
Subjects:
histone deacetylases
histone deacetylase inhibitors
double-strand break repair
cohesion
sister-chromatid recombination
Online Access:http://dx.doi.org/10.1080/23723556.2019.1705731
Description
Summary:We have recently uncovered that loss of the yeast histone deacetylases Rpd3 (Reduced Potassium Dependency 3) and Hda1 (Histone DeAcetylase 3) affects the cohesion between sister chromatids thus impairing repair of DNA damage at replication forks and enhancing genetic instability. Here we discuss the possible implications of our findings given that histone deacetylases are a promising chemotherapeutic target often used in combination with DNA damaging agents.
ISSN:2372-3556

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