Histone deacetylases facilitate the accurate repair of broken forks
We have recently uncovered that loss of the yeast histone deacetylases Rpd3 (Reduced Potassium Dependency 3) and Hda1 (Histone DeAcetylase 3) affects the cohesion between sister chromatids thus impairing repair of DNA damage at replication forks and enhancing genetic instability. Here we discuss the...
| Published in: | Molecular & Cellular Oncology |
|---|---|
| Main Authors: | , , |
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2020-03-01
|
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2019.1705731 |
| _version_ | 1850301627080114176 |
|---|---|
| author | Belén Gómez-González Pedro Ortega Andrés Aguilera |
| author_facet | Belén Gómez-González Pedro Ortega Andrés Aguilera |
| author_sort | Belén Gómez-González |
| collection | DOAJ |
| container_title | Molecular & Cellular Oncology |
| description | We have recently uncovered that loss of the yeast histone deacetylases Rpd3 (Reduced Potassium Dependency 3) and Hda1 (Histone DeAcetylase 3) affects the cohesion between sister chromatids thus impairing repair of DNA damage at replication forks and enhancing genetic instability. Here we discuss the possible implications of our findings given that histone deacetylases are a promising chemotherapeutic target often used in combination with DNA damaging agents. |
| format | Article |
| id | doaj-art-45bcaba4d7f7418aa34aeff858428c8d |
| institution | Directory of Open Access Journals |
| issn | 2372-3556 |
| language | English |
| publishDate | 2020-03-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| spelling | doaj-art-45bcaba4d7f7418aa34aeff858428c8d2025-08-19T23:30:56ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562020-03-017210.1080/23723556.2019.17057311705731Histone deacetylases facilitate the accurate repair of broken forksBelén Gómez-González0Pedro Ortega1Andrés Aguilera2Universidad de Sevilla-CSIC-Universidad Pablo de OlavideUniversidad de Sevilla-CSIC-Universidad Pablo de OlavideUniversidad de Sevilla-CSIC-Universidad Pablo de OlavideWe have recently uncovered that loss of the yeast histone deacetylases Rpd3 (Reduced Potassium Dependency 3) and Hda1 (Histone DeAcetylase 3) affects the cohesion between sister chromatids thus impairing repair of DNA damage at replication forks and enhancing genetic instability. Here we discuss the possible implications of our findings given that histone deacetylases are a promising chemotherapeutic target often used in combination with DNA damaging agents.http://dx.doi.org/10.1080/23723556.2019.1705731histone deacetylaseshistone deacetylase inhibitorsdouble-strand break repaircohesionsister-chromatid recombination |
| spellingShingle | Belén Gómez-González Pedro Ortega Andrés Aguilera Histone deacetylases facilitate the accurate repair of broken forks histone deacetylases histone deacetylase inhibitors double-strand break repair cohesion sister-chromatid recombination |
| title | Histone deacetylases facilitate the accurate repair of broken forks |
| title_full | Histone deacetylases facilitate the accurate repair of broken forks |
| title_fullStr | Histone deacetylases facilitate the accurate repair of broken forks |
| title_full_unstemmed | Histone deacetylases facilitate the accurate repair of broken forks |
| title_short | Histone deacetylases facilitate the accurate repair of broken forks |
| title_sort | histone deacetylases facilitate the accurate repair of broken forks |
| topic | histone deacetylases histone deacetylase inhibitors double-strand break repair cohesion sister-chromatid recombination |
| url | http://dx.doi.org/10.1080/23723556.2019.1705731 |
| work_keys_str_mv | AT belengomezgonzalez histonedeacetylasesfacilitatetheaccuraterepairofbrokenforks AT pedroortega histonedeacetylasesfacilitatetheaccuraterepairofbrokenforks AT andresaguilera histonedeacetylasesfacilitatetheaccuraterepairofbrokenforks |