Tricyclic Pyrazole-Based Compounds as Useful Scaffolds for Cannabinoid CB<sub>1</sub>/CB<sub>2</sub> Receptor Interaction

Cannabinoids comprise different classes of compounds, which aroused interest in recent years because of their several pharmacological properties. Such properties include analgesic activity, bodyweight reduction, the antiemetic effect, the reduction of intraocular pressure and many others, which appe...

書目詳細資料
發表在:	Molecules
Main Authors:	Battistina Asproni, Gabriele Murineddu, Paola Corona, Gérard A. Pinna
格式:	Article
語言:	英语
出版:	MDPI AG 2021-04-01
主題:	tricyclic pyrazoles structure-activity relationship CB<sub>2</sub> agonist CB<sub>1</sub> agonist CB<sub>1</sub> neutral antagonist anti-nociceptive activity
在線閱讀:	https://www.mdpi.com/1420-3049/26/8/2126

相似書籍

Requiem for Rimonabant: Therapeutic Potential for Cannabinoid CB<sub>1</sub> Receptor Antagonists after the Fall
由: Taryn Bosquez-Berger, et al.
出版: (2023-08-01)

Characterization of Subtype Selective Cannabinoid CB<sub>2</sub> Receptor Agonists as Potential Anti-Inflammatory Agents
由: Yaliang Tang, et al.
出版: (2021-04-01)

Expression of Functional Cannabinoid Type-1 (CB<sub>1</sub>) Receptor in Mitochondria of White Adipocytes
由: Antonio C. Pagano Zottola, et al.
出版: (2022-08-01)

The Peripheral Cannabinoid Receptor Type 1 (CB<sub>1</sub>) as a Molecular Target for Modulating Body Weight in Man
由: Saoirse Elizabeth O’Sullivan, et al.
出版: (2021-10-01)

Confound, Cause, or Cure: The Effect of Cannabinoids on HIV-Associated Neurological Sequelae
由: Alexander Starr, et al.
出版: (2021-06-01)

2-Arylpropionic Acid Pyrazolamides as Cannabinoid CB2 Receptor Inverse Agonists Endowed with Anti-Inflammatory Properties
由: Daniela R. de Oliveira, et al.
出版: (2022-12-01)

A Robust and Efficient FRET-Based Assay for Cannabinoid Receptor Ligands Discovery
由: Gemma Navarro, et al.
出版: (2023-12-01)

A Simple and Efficient Way to Directly Synthesize Unsolvated Alkali Metal (M = Na, K) Salts of [CB<sub>11</sub>H<sub>12</sub>]<sup>−</sup>
由: Hui Han, et al.
出版: (2022-09-01)

Cross-Talk between CB<sub>1</sub>, AT<sub>1</sub>, AT<sub>2</sub> and Mas Receptors Responsible for Blood Pressure Control in the Paraventricular Nucleus of Hypothalamus in Conscious Spontaneously Hypertensive Rats and Their Normotensive Controls
由: Krzysztof Mińczuk, et al.
出版: (2022-05-01)

Angiotensin II-Induced Cardiac Effects Are Modulated by Endocannabinoid-Mediated CB<sub>1</sub> Receptor Activation
由: Zsuzsanna Miklós, et al.
出版: (2021-03-01)

Roles of the Hepatic Endocannabinoid and Apelin Systems in the Pathogenesis of Liver Fibrosis
由: Pedro Melgar-Lesmes, et al.
出版: (2019-10-01)

Therapeutic Attributes of Endocannabinoid System against Neuro-Inflammatory Autoimmune Disorders
由: Ishtiaq Ahmed, et al.
出版: (2021-06-01)

Cannabis, Endocannabinoids and Brain Development: From Embryogenesis to Adolescence
由: Ricardo J. Rodrigues, et al.
出版: (2024-11-01)

Anti-Inflammatory Activity of a CB2 Selective Cannabinoid Receptor Agonist: Signaling and Cytokines Release in Blood Mononuclear Cells
由: Antonella Capozzi, et al.
出版: (2021-12-01)

Revealing the therapeutic potential of synthetic cannabinoids: a systematic review of cannabinoid receptor binding dynamics and their implications for cancer therapy
由: Sahar S. Alghamdi, et al.
出版: (2025-06-01)

Role of 5-HT<sub>1A</sub> and 5-HT<sub>7</sub> Receptors in Memory Regulation and the Importance of Their Coexpression: A Systematic Review
由: Alfredo Briones-Aranda, et al.
出版: (2025-05-01)

Type 2 Diabetes Alters Vascular Cannabinoid Receptor 1 Expression, Phosphorylation Status, and Vasorelaxation in Rat Aorta
由: Enrique Sánchez-Pastor, et al.
出版: (2020-10-01)

Structure–Activity Relationship Development Efforts towards Peripherally Selective Analogs of the Cannabinoid Receptor Partial Agonist BAY 59-3074
由: George Amato, et al.
出版: (2022-09-01)

The role of cannabinoid agonists and antagonists on folliculogenesis and evolutionary events in the mouse ovary
由: Vida Mirzaie, et al.
出版: (2025-09-01)

Adenosine Receptors as Neuroinflammation Modulators: Role of A<sub>1</sub> Agonists and A<sub>2A</sub> Antagonists
由: Aleix Martí Navia, et al.
出版: (2020-07-01)

Combined Therapy of A<sub>1</sub>AR Agonists and A<sub>2A</sub>AR Antagonists in Neuroinflammation
由: Gabriella Marucci, et al.
出版: (2021-02-01)

Evaluating signaling bias for synthetic cannabinoid receptor agonists at the cannabinoid CB2 receptor
由: Monica Patel, et al.
出版: (2023-12-01)

Activation of the Rat α1β2ε GABA<sub>A</sub> Receptor by Orthosteric and Allosteric Agonists
由: Allison L. Germann, et al.
出版: (2022-06-01)

Activation of the α1β2γ2L GABA<sub>A</sub> Receptor by Physiological Agonists
由: Spencer R. Pierce, et al.
出版: (2021-12-01)

Cannabinoid Receptor 2 Alters Social Memory and Microglial Activity in an Age-Dependent Manner
由: Joanna Agnieszka Komorowska-Müller, et al.
出版: (2021-10-01)

Sex differences in distribution of cannabinoid receptors (CB1 and CB2), S100A6 and CacyBP/SIP in human ageing hearts
由: Żaneta Piotrowska, et al.
出版: (2018-11-01)

CB1 Agonism Alters Addiction-Related Behaviors in Mice Lacking Mu or Delta Opioid Receptors
由: Laurie-Anne Roeckel, et al.
出版: (2018-11-01)

Cannabinoid CB1 Receptor Expression and Localization in the Dorsal Horn of Male and Female Rat and Human Spinal Cord
由: Jessica Parnell, et al.
出版: (2023-07-01)

Cannabinoid Receptor Modulation of Neurogenesis: ST14A Striatal Neural Progenitor Cells as a Simplified In Vitro Model
由: Erika Cottone, et al.
出版: (2021-03-01)

Synthesis and In Vitro Characterization of Selective Cannabinoid CB2 Receptor Agonists: Biological Evaluation against Neuroblastoma Cancer Cells
由: Francesca Gado, et al.
出版: (2022-05-01)

Editorial: Therapeutic potential of the cannabinoid CB2 receptor
由: Reem Smoum, et al.
出版: (2022-10-01)

Involvement of CB1R and CB2R Ligands in Sleep Disorders and Addictive Behaviors in the Last 25 Years
由: Marcel Pérez-Morales, et al.
出版: (2025-02-01)

Cancer-Cachexia-Induced Human Skeletal Muscle Myotube Degeneration Is Prevented via Cannabinoid Receptor 2 Agonism In Vitro
由: John Noone, et al.
出版: (2023-11-01)

Synthesis of Chitosan-La<sub>2</sub>O<sub>3</sub> Nanocomposite and Its Utility as a Powerful Catalyst in the Synthesis of Pyridines and Pyrazoles
由: Khaled D. Khalil, et al.
出版: (2021-06-01)

CB1 receptor and psychosis: friend, foe, or both
由: Jagadeesh S. Rao, et al.
出版: (2025-07-01)

Role of the Endocannabinoid System in Metabolic Control Processes and in the Pathogenesis of Metabolic Syndrome: An Update
由: Gabriella Dörnyei, et al.
出版: (2023-01-01)

Fenchone Derivatives as a Novel Class of CB2 Selective Ligands: Design, Synthesis, X-ray Structure and Therapeutic Potential
由: Reem Smoum, et al.
出版: (2022-02-01)

Anti-apoptotic and Immunomodulatory Effect of CB2 Agonist, JWH133, in a Neonatal Rat Model of Hypoxic-Ischemic Encephalopathy
由: Bhavna Gupta, et al.
出版: (2020-02-01)

Dopamine D<sub>1</sub> Agonists: First Potential Treatment for Late-Stage Parkinson’s Disease
由: Mechelle M. Lewis, et al.
出版: (2023-05-01)

<i>Cannabis sativa</i>: Interdisciplinary Strategies and Avenues for Medical and Commercial Progression Outside of CBD and THC
由: Jackson M. J. Oultram, et al.
出版: (2021-02-01)