Expression of B-RAF V600E in type II pneumocytes causes abnormalities in alveolar formation, airspace enlargement and tumor formation in mice.

Growth factor induced signaling cascades are key regulatory elements in tissue development, maintenance and regeneration. Perturbations of these cascades have severe consequences, leading to developmental disorders and neoplastic diseases. As a major function in signal transduction, activating mutat...

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Bibliographic Details

Published in:	PLoS ONE
Main Authors:	Emanuele Zanucco, Rudolf Götz, Tamara Potapenko, Irene Carraretto, Semra Ceteci, Fatih Ceteci, Werner Seeger, Rajkumar Savai, Ulf R Rapp
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2011-01-01
Online Access:	http://europepmc.org/articles/PMC3237599?pdf=render