Focal therapy of prostate cancer: Assessment with prostate-specific membrane antigen (PSMA) imaging

• 出版年: Urology Case Reports
• 主要な著者: Mark Topoozian, Jeremie Calais, Ely Felker, Anthony Sisk, Samantha Gonzalez, Sean J. Lee, Leonard S. Marks
• フォーマット: 論文
• 言語: 英語
• 出版事項: Elsevier 2023-09-01
• 主題: Prostate cancer; Focal therapy; PSMA; HIFU
• オンライン･アクセス: http://www.sciencedirect.com/science/article/pii/S221444202300147X
• ISSN: 2214-4420

Focal therapy of prostate cancer (PCa) is currently of great interest, but a metric of success. other than biopsy, is not yet available. In a patient with a repeatedly negative MRI and negative systematic biopsies, a scan employing the radioisotope 68Ga-PSMA-11 PET/CT identified a PSMA-avid hotspot in the prostate. PSMA-guided biopsy confirmed the diagnosis of a clinically-significant PCa. Following ablation of the lesion with high-intensity focused ultrasound (HIFU), the PSMA-avid lesion disappeared and targeted biopsy confirmed a fibrotic scar with no residual cancer. PSMA imaging may have a role in guiding diagnosis, focal ablation, and follow-up of men with PCa.