The different variant allele frequencies of type I/type II mutations and the distinct molecular landscapes in CALR-mutant essential thrombocythaemia and primary myelofibrosis

Objective Calreticulin (CALR) mutations have been identified as driver mutations in a quarter of patients with essential thrombocythaemia (ET) and primary myelofibrosis (PMF), which are subgroups of myeloproliferative neoplasms (MPNs). A 52-bp deletion (type I mutation) and a 5-bp insertion (type II...

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Bibliographic Details
Published in:Hematology
Main Authors: Yuxia Pan, Xingzhe Wang, Shupeng Wen, Xiaojun Liu, Lin Yang, Jianmin Luo
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Subjects:
CALR
variant allele frequency
non-driver mutation
essential thrombocythaemia
primary myelofibrosis
Online Access:https://www.tandfonline.com/doi/10.1080/16078454.2022.2107888

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