Cytotoxicity study of reaction products between isatin and furan
Isatin, 5-chloroisatin, 7-bromoisatin and 7-ethylisatin on treatment with furan in presence of diethylamine yield furan moiety inclusion products bis-diisatin [3,3´] furan, bis-[5,5´] dichlorodiisatin [3,3´] furan, bis-[7,7´] dibromodiisatin [3,3´] furan and bis-[7,7´] diethyldiisatin [3,3´] furan r...
| 出版年: | Bangladesh Journal of Pharmacology |
|---|---|
| 主要な著者: | , , |
| フォーマット: | 論文 |
| 言語: | 英語 |
| 出版事項: |
Bangladesh Pharmacological Society
2009-04-01
|
| 主題: | |
| オンライン･アクセス: | https://www.banglajol.info/index.php/BJP/article/view/2381 |
| _version_ | 1856911468979552256 |
|---|---|
| author | Md. Arifuzzaman Rafiya Khan Kandahary Md. Rabiul Islam |
| author_facet | Md. Arifuzzaman Rafiya Khan Kandahary Md. Rabiul Islam |
| author_sort | Md. Arifuzzaman |
| collection | DOAJ |
| container_title | Bangladesh Journal of Pharmacology |
| description | Isatin, 5-chloroisatin, 7-bromoisatin and 7-ethylisatin on treatment with furan in presence of diethylamine yield furan moiety inclusion products bis-diisatin [3,3´] furan, bis-[5,5´] dichlorodiisatin [3,3´] furan, bis-[7,7´] dibromodiisatin [3,3´] furan and bis-[7,7´] diethyldiisatin [3,3´] furan respectively in moderate yields. The cytotoxicity of these compounds was studied by the brine shrimp lethality bioassay and the Structure Activity Relationships (SAR) of these compounds has been discussed. The present study shows that the compound bis-[7,7´] dibromodiisatin [3,3´] furan had pronounced cytotoxicity whereas compounds bis-[5,5´] dichlorodiisatin [3,3´] furan and bis-[7,7´] diethyldiisatin [3,3´] furan were moderately active. It is remarkable that the constituent, Y = -Br at seven position in the benzene ring has greater activity than ethyl and chlorine atom. |
| format | Article |
| id | doaj-art-487f7dd8cfcc4a2e9d16bdcccb8ce72b |
| institution | Directory of Open Access Journals |
| issn | 1991-0088 |
| language | English |
| publishDate | 2009-04-01 |
| publisher | Bangladesh Pharmacological Society |
| record_format | Article |
| spelling | doaj-art-487f7dd8cfcc4a2e9d16bdcccb8ce72b2025-08-19T20:20:33ZengBangladesh Pharmacological SocietyBangladesh Journal of Pharmacology1991-00882009-04-014210.3329/bjp.v4i2.2381Cytotoxicity study of reaction products between isatin and furanMd. Arifuzzaman0Rafiya Khan Kandahary1Md. Rabiul Islam2Department of Chemistry, Jahangirnagar University, Savar, Dhaka 1342Department of Chemistry, Jahangirnagar University, Savar, Dhaka 1342Department of Chemistry, Jahangirnagar University, Savar, Dhaka 1342Isatin, 5-chloroisatin, 7-bromoisatin and 7-ethylisatin on treatment with furan in presence of diethylamine yield furan moiety inclusion products bis-diisatin [3,3´] furan, bis-[5,5´] dichlorodiisatin [3,3´] furan, bis-[7,7´] dibromodiisatin [3,3´] furan and bis-[7,7´] diethyldiisatin [3,3´] furan respectively in moderate yields. The cytotoxicity of these compounds was studied by the brine shrimp lethality bioassay and the Structure Activity Relationships (SAR) of these compounds has been discussed. The present study shows that the compound bis-[7,7´] dibromodiisatin [3,3´] furan had pronounced cytotoxicity whereas compounds bis-[5,5´] dichlorodiisatin [3,3´] furan and bis-[7,7´] diethyldiisatin [3,3´] furan were moderately active. It is remarkable that the constituent, Y = -Br at seven position in the benzene ring has greater activity than ethyl and chlorine atom.https://www.banglajol.info/index.php/BJP/article/view/2381Brine shrimpCytotoxicityFuran insertionIsatin |
| spellingShingle | Md. Arifuzzaman Rafiya Khan Kandahary Md. Rabiul Islam Cytotoxicity study of reaction products between isatin and furan Brine shrimp Cytotoxicity Furan insertion Isatin |
| title | Cytotoxicity study of reaction products between isatin and furan |
| title_full | Cytotoxicity study of reaction products between isatin and furan |
| title_fullStr | Cytotoxicity study of reaction products between isatin and furan |
| title_full_unstemmed | Cytotoxicity study of reaction products between isatin and furan |
| title_short | Cytotoxicity study of reaction products between isatin and furan |
| title_sort | cytotoxicity study of reaction products between isatin and furan |
| topic | Brine shrimp Cytotoxicity Furan insertion Isatin |
| url | https://www.banglajol.info/index.php/BJP/article/view/2381 |
| work_keys_str_mv | AT mdarifuzzaman cytotoxicitystudyofreactionproductsbetweenisatinandfuran AT rafiyakhankandahary cytotoxicitystudyofreactionproductsbetweenisatinandfuran AT mdrabiulislam cytotoxicitystudyofreactionproductsbetweenisatinandfuran |