Design and synthesis of a novel quinoline thiazolidinedione hybrid as a potential antidiabetic PPARγ modulator

Abstract Peroxisome proliferator-activated receptor γ (PPARγ) remains a critical target for antidiabetic drug development due to its role in glucose and lipid metabolism. However, the adverse effects associated with full agonists of the thiazolidinedione (TZD) class, such as weight gain and hepatoto...

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出版年:	Scientific Reports
主要な著者:	Ayman M. Ibrahim, Mai E. Shoman, Radwa Taher Mohie el-dien, Entesar Ali Saber, Mahmoud Abdelnaser, Sherif A. Maher, Alaa M. Hayallah, Mahmoud Abdul-Aziz El-Rehany, Gamal El-Din A. Abuo-Rahma
フォーマット:	論文
言語:	英語
出版事項:	Nature Portfolio 2025-06-01
主題:	Quinoline Thiazolidinedione PPARγ Antidiabetic SPPARMs
オンライン･アクセス:	https://doi.org/10.1038/s41598-025-03387-9