Wnt4 is heterogeneously activated in maturing β-cells to control calcium signaling, metabolism and function
Diabetes is characterized by loss or dysfunction of pancreatic β-cells. Here the authors show that the signalling protein WNT4 is heterogeneously activated by β-cells during their postnatal maturation with WNT4 positive cells being more mature, and that inactivating WNT4 in β-cells after maturation...
Full description
Bibliographic Details
| Published in: | Nature Communications |
|---|
| Main Authors: |
Keiichi Katsumoto,
Siham Yennek,
Chunguang Chen,
Luis Fernando Delgadillo Silva,
Sofia Traikov,
Dror Sever,
Ajuna Azad,
Jingdong Shan,
Seppo Vainio,
Nikolay Ninov,
Stephan Speier,
Anne Grapin-Botton |
|---|
| Format: | Article
|
|---|
| Language: | English |
|---|
| Published: |
Nature Portfolio
2022-10-01
|
|---|
| Online Access: | https://doi.org/10.1038/s41467-022-33841-5
|
|---|
