沙棘亚麻籽油软胶囊降血脂功能及其安全性评价Lipidlowering function and safety evaluation of sea buckthorn flaxseed oil soft capsule

为了开发降血脂食品，以沙棘籽油、亚麻籽油为主要原料，并以天然维生素E、明胶、纯净水、甘油等为辅料制成沙棘亚麻籽油软胶囊，以雄性SD大鼠为实验动物，对沙棘亚麻籽油软胶囊的降血脂功能进行评价，再通过小鼠急性经口毒性实验、遗传毒性实验和大鼠30 d喂养实验对其毒理性进行评价，并选择110例符合纳入标准的高脂血症患者，连续服用沙棘亚麻籽油软胶囊45 d后测定相应指标，评价其对人体的降血脂功能和安全性。结果表明：高剂量组(0.667 g/kg)大鼠血清中TC、TG和LDL-C含量分别平均下降了15.6%、22.3%、29.0%，与模型对照组相比均差异极显著(p<0.01)；毒理学实验结果显示沙棘亚...

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Bibliographic Details
Published in:	Zhongguo youzhi
Main Author:	侯兴琳1,张同军2,兰莹1 HOU Xinglin1 , ZHANG Tongjun2, LAN Ying1
Format:	Article
Language:	English
Published:	中粮工科（西安）国际工程有限公司 2022-11-01
Subjects:	沙棘籽油；亚麻籽油；降血脂；急性毒性；遗传毒性；人体试食 sea buckthorn seed oil; flaxseed oil; lipid-lowering; acute toxicity; genotoxicity; human experiment
Online Access:	http://tg.chinaoils.cn/ch/reader/create_pdf.aspx?file_no=20221106&year_id=2022&quarter_id=11&falg=1

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