Monoindole Alkaloids from a Marine Sponge Spongosorites sp.

Seven (1−7) monoindole derivatives were isolated from the MeOH extract of a marine sponge Spongosorites sp. by bioactivity-guided fractionation. The planar structures were established on the basis of NMR and MS spectroscopic analyses. Compounds 1−5 are unique indole pyruvic acid derivative...

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Bibliographic Details
Published in:Marine Drugs
Main Authors: Jee H. Jung, Chong-O. Lee, Jongki Hong, Yoonmi Lee, Ping Zhang, Baoquan Bao
Format: Article
Language:English
Published: MDPI AG 2007-06-01
Subjects:
Marine sponge
Spongosorites
monoindole alkaloids
cytotoxicity.
Online Access:http://www.mdpi.com/1660-3397/5/2/31/
Description
Summary:Seven (1−7) monoindole derivatives were isolated from the MeOH extract of a marine sponge Spongosorites sp. by bioactivity-guided fractionation. The planar structures were established on the basis of NMR and MS spectroscopic analyses. Compounds 1−5 are unique indole pyruvic acid derivatives. Compounds 1−2 and 4−6 are isolated for the first time from a natural source although they were previously reported as synthetic intermediates. Compound 3 was defined as a new compound. Co-occurring bisindoles such as hamacanthins and topsentins might be biosynthesized by condensation of two units of these compounds. The compounds were tested for cytotoxicity against a panel of five human solid tumor cell lines, and compound 7 displayed weak activity.
ISSN:1660-3397

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