Preparation and Characterization of Site-Specific Fatty Chain-Modified Recombinant Human Granulocyte Colony Stimulating Factor

The clinical use of recombinant human granulocyte colony-stimulating factor (rhG-CSF) is limited by its short serum half-life. In this study, a long-acting strategy for site-specific modification of rhG-CSF with 1-pentadecyl-1H-pyrrole-2,5-dione (C15 fatty chain-maleimide, C15-MAL) was studied in mi...

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Bibliographic Details

Published in:	Frontiers in Bioengineering and Biotechnology
Main Authors:	Xu-Dong Wang, Wei-Jia Yu, Jia-Hui Liu, Jie Du, Kang-Nan Chen, Qin-Qin Hu, Wen-Long Sun, Guo-Qing Ying
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-05-01
Subjects:	rhG-CSF recombinant human granulocyte colony stimulating factor fatty chain fatty chain modification site-specific modification thiol modification
Online Access:	https://www.frontiersin.org/articles/10.3389/fbioe.2022.923059/full