Hippocampal tau oligomerization early in tau pathology coincides with a transient alteration of mitochondrial homeostasis and DNA repair in a mouse model of tauopathy

Abstract Insoluble intracellular aggregation of tau proteins into filaments and neurodegeneration are histopathological hallmarks of Alzheimer disease (AD) and other tauopathies. Recently, prefibrillar, soluble, oligomeric tau intermediates have emerged as relevant pathological tau species; however,...

書目詳細資料
發表在:	Acta Neuropathologica Communications
Main Authors:	Jin Zheng, Mansour Akbari, Claire Schirmer, Marie-Line Reynaert, Anne Loyens, Bruno Lefebvre, Luc Buée, Deborah L. Croteau, Marie-Christine Galas, Vilhelm A. Bohr
格式:	Article
語言:	英语
出版:	BMC 2020-03-01
主題:	Tau oligomerization Mitochondrial homeostasis Polymerase beta Oxidative stress Tauopathies
在線閱讀:	http://link.springer.com/article/10.1186/s40478-020-00896-8

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