Platinum-Catalyzed Allylation of 2,3-Disubstituted Indoles with Allylic Acetates
Given the importance of heterocycle indole derivatives, much effort has been directed toward the development of methods for functionalization of the indole nucleus at N1 and C3 sites. Moreover, the platinum-catalyzed allyation of nucleophiles was an established and efficient way, which has been appl...
| Published in: | Molecules |
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| Main Authors: | , , |
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2017-11-01
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| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/22/12/2097 |
| _version_ | 1857046313109028864 |
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| author | Bai-Jing Peng Wen-Ting Wu Shyh-Chyun Yang |
| author_facet | Bai-Jing Peng Wen-Ting Wu Shyh-Chyun Yang |
| author_sort | Bai-Jing Peng |
| collection | DOAJ |
| container_title | Molecules |
| description | Given the importance of heterocycle indole derivatives, much effort has been directed toward the development of methods for functionalization of the indole nucleus at N1 and C3 sites. Moreover, the platinum-catalyzed allyation of nucleophiles was an established and efficient way, which has been applied to medicinal and organic chemistry. In our research, the platinum-catalyzed 2,3-disubstitued indoles with allylic acetates was investigated under different conditions. Herein, we established a simple, convenient, and efficient method, which afforded high yield of allylated indoles. |
| format | Article |
| id | doaj-art-4e34fdc1c4ff47b0a495a4e296fcbbbc |
| institution | Directory of Open Access Journals |
| issn | 1420-3049 |
| language | English |
| publishDate | 2017-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| spelling | doaj-art-4e34fdc1c4ff47b0a495a4e296fcbbbc2025-08-19T19:34:32ZengMDPI AGMolecules1420-30492017-11-012212209710.3390/molecules22122097molecules22122097Platinum-Catalyzed Allylation of 2,3-Disubstituted Indoles with Allylic AcetatesBai-Jing Peng0Wen-Ting Wu1Shyh-Chyun Yang2School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, TaiwanSchool of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, TaiwanSchool of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, TaiwanGiven the importance of heterocycle indole derivatives, much effort has been directed toward the development of methods for functionalization of the indole nucleus at N1 and C3 sites. Moreover, the platinum-catalyzed allyation of nucleophiles was an established and efficient way, which has been applied to medicinal and organic chemistry. In our research, the platinum-catalyzed 2,3-disubstitued indoles with allylic acetates was investigated under different conditions. Herein, we established a simple, convenient, and efficient method, which afforded high yield of allylated indoles.https://www.mdpi.com/1420-3049/22/12/2097platinum-catalyzedindole derivativesallylic acetatesallylation |
| spellingShingle | Bai-Jing Peng Wen-Ting Wu Shyh-Chyun Yang Platinum-Catalyzed Allylation of 2,3-Disubstituted Indoles with Allylic Acetates platinum-catalyzed indole derivatives allylic acetates allylation |
| title | Platinum-Catalyzed Allylation of 2,3-Disubstituted Indoles with Allylic Acetates |
| title_full | Platinum-Catalyzed Allylation of 2,3-Disubstituted Indoles with Allylic Acetates |
| title_fullStr | Platinum-Catalyzed Allylation of 2,3-Disubstituted Indoles with Allylic Acetates |
| title_full_unstemmed | Platinum-Catalyzed Allylation of 2,3-Disubstituted Indoles with Allylic Acetates |
| title_short | Platinum-Catalyzed Allylation of 2,3-Disubstituted Indoles with Allylic Acetates |
| title_sort | platinum catalyzed allylation of 2 3 disubstituted indoles with allylic acetates |
| topic | platinum-catalyzed indole derivatives allylic acetates allylation |
| url | https://www.mdpi.com/1420-3049/22/12/2097 |
| work_keys_str_mv | AT baijingpeng platinumcatalyzedallylationof23disubstitutedindoleswithallylicacetates AT wentingwu platinumcatalyzedallylationof23disubstitutedindoleswithallylicacetates AT shyhchyunyang platinumcatalyzedallylationof23disubstitutedindoleswithallylicacetates |