Reducing stroke burden through a targeted self-management intervention for reducing stroke risk factors in high-risk Ugandans: A protocol for a randomized controlled trial.

• Published in: PLoS ONE
• Main Authors: Mark Kaddumukasa, Josephine Najjuma, Scovia Nalugo Mbalinda, Martin N Kaddumukasa, Jane Nakibuuka, Christopher Burant, Shirley Moore, Carol Blixen, Elly T Katabira, Martha Sajatovic
• Format: Article
• Language: English
• Published: Public Library of Science (PLoS) 2021-01-01
• Online Access: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0251662&type=printable
• ISSN: 1932-6203

<h4>Introduction</h4>Stroke burden is rapidly increasing globally. Modifiable risk factors offer an opportunity to intervene, and targeting hypertension is a key actionable target for stroke risk reduction in sub-Saharan Africa. This 3-site planned randomized controlled trial builds on promising preliminary data.<h4>Methods</h4>A total of 246 Ugandan adults will be recruited randomized to experimental intervention vs. enhanced treatment control. Intervention participants will receive six weekly group-format stroke risk reduction self-management training sessions, and the controls will receive information on cardiovascular risk. The primary study outcome is systolic B.P. measured at baseline, 13-week, 24 weeks (6 months). Secondary outcomes include other biological and behavioral stroke risk factors.<h4>Discussion</h4>The curriculum-guided self-management TargetEd MAnageMent Intervention (TEAM) program is anticipated to reduce the stroke burden in Uganda.<h4>Trial registration</h4>ClinicalTrials.gov identifier: NCT04685408, registered on 28 December 2020.