Simple and efficient synthesis of 3,4-dihydropyrimidin-2(1H)-thiones utilizing l-proline nitrate as a proficient, recyclable and eco-friendly catalyst

A convenient method has been described for eco-friendly synthesis of 3,4-dihydropyrimidin-2(1H)-thiones in the presence of l-proline nitrate as a green amino acid ionic liquid (AAIL) under mild conditions. This greener synthetic method offers benefits like higher yields, shorter reaction times and s...

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Bibliographic Details
Published in:Journal of Saudi Chemical Society
Main Authors: Sandeep P. Bahekar, Prashant B. Sarode, Murlidhar P. Wadekar, Hemant S. Chandak
Format: Article
Language:English
Published: Springer 2017-05-01
Subjects:
Amino acid ionic liquid
l-Proline nitrate
3,4-Dihydropyrimidin-2(1H)-thione
Biginelli reaction
Multi-component reaction
Online Access:http://www.sciencedirect.com/science/article/pii/S1319610315001143
Description
Summary:A convenient method has been described for eco-friendly synthesis of 3,4-dihydropyrimidin-2(1H)-thiones in the presence of l-proline nitrate as a green amino acid ionic liquid (AAIL) under mild conditions. This greener synthetic method offers benefits like higher yields, shorter reaction times and simple work-up. Easy recyclability of the bio-compatible catalyst makes this protocol attractive, economic and environmentally-benign.
ISSN:1319-6103

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