Looking beyond silybin: the importance of other silymarin flavonolignans

Silymarin, an extract from the seeds of milk thistle (Silybum marianum), has been widely studied and used for its hepatoprotective and pharmacological properties. For decades, both experimental and clinical research has been predominantly focused on a single component, silybin, while other related f...

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:	Frontiers in Pharmacology
المؤلفون الرئيسيون:	Michal Selc, Andrea Babelova
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	Frontiers Media S.A. 2025-07-01
الموضوعات:	silymarin silybin flavonolignans natural products research bias
الوصول للمادة أونلاين:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1637393/full

مواد مشابهة

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منشور في: (2017-08-01)

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2,3-Dehydroderivatives of Silymarin Flavonolignans: Prospective Natural Compounds for the Prevention of Chronic Diseases
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منشور في: (2020-01-01)

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cis–trans Isomerization of silybins A and B
حسب: Michaela Novotná, وآخرون
منشور في: (2014-05-01)

Dose Effect of Milk Thistle (<i>Silybum marianum</i>) Seed Cakes on the Digestibility of Nutrients, Flavonolignans and the Individual Components of the Silymarin Complex in Horses
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منشور في: (2021-06-01)

Influence of Plant Growth Regulators on Callus Induction, Silymarin Production and Antioxidant Activity in Milk Thistle (Silybum marianum L. Gaertn.) under Tissue Culture Medium
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Novel Strategies Enhancing Bioavailability and Therapeutical Potential of Silibinin for Treatment of Liver Disorders
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Dehydroflavonolignans from Silymarin Potentiate Transition Metal Toxicity In Vitro but Are Protective for Isolated Erythrocytes Ex Vivo
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منشور في: (2021-04-01)

Preparation of Retinoyl-Flavonolignan Hybrids and Their Antioxidant Properties
حسب: Christopher S. Chambers, وآخرون
منشور في: (2019-07-01)

Identification of Human Sulfotransferases Active towards Silymarin Flavonolignans and Taxifolin
حسب: Jiří Vrba, وآخرون
منشور في: (2020-08-01)

Silymarin and Cancer: A Dual Strategy in Both in Chemoprevention and Chemosensitivity
حسب: Dominique Delmas, وآخرون
منشور في: (2020-04-01)

Mechanistic Insights into the Pharmacological Significance of Silymarin
حسب: Karan Wadhwa, وآخرون
منشور في: (2022-08-01)

A systematic review of silymarin and silibinin mechanisms for attenuating cerebral ischemia-reperfusion injuries
حسب: Hossein Mardani-Nafchi, وآخرون
منشور في: (2025-07-01)

HM015k, a Novel Silybin Derivative, Multi-Targets Metastatic Ovarian Cancer Cells and Is Safe in Zebrafish Toxicity Studies
حسب: Haneen Amawi, وآخرون
منشور في: (2017-08-01)

In-Vitro Activity of Silybin and Related Flavonolignans against Leishmania infantum and L. donovani
حسب: Ana Isabel Olías-Molero, وآخرون
منشور في: (2018-06-01)

Silymarin as a Natural Antioxidant: An Overview of the Current Evidence and Perspectives
حسب: Peter F. Surai
منشور في: (2015-03-01)

A Green Ultrasound-Assisted Extraction Optimization of the Natural Antioxidant and Anti-Aging Flavonolignans from Milk Thistle <i>Silybum marianum</i> (L.) Gaertn. Fruits for Cosmetic Applications
حسب: Samantha Drouet, وآخرون
منشور في: (2019-08-01)

Flavonolignans silybin, silychristin and 2,3-dehydrosilybin showed differential cytoprotective, antioxidant and anti-apoptotic effects on splenocytes from Balb/c mice
حسب: Zuzana Jurčacková, وآخرون
منشور في: (2025-02-01)

Anti-Viral Activity of Bioactive Molecules of Silymarin against COVID-19 via In Silico Studies
حسب: Chunye Zhang, وآخرون
منشور في: (2023-10-01)

The Influence of Fructose, Glucose and Sucrose on Flavonolignans Formation in Silybum marianum Callus Culture
حسب: G Asghari, وآخرون
منشور في: (2008-05-01)

Protective Effect of Silybin in Rats Liver Toxicity
حسب: Roxana Popescu, وآخرون
منشور في: (2023-10-01)

Lipid-Based Delivery Systems for Flavonoids and Flavonolignans: Liposomes, Nanoemulsions, and Solid Lipid Nanoparticles
حسب: Shahla Ranjbar, وآخرون
منشور في: (2023-07-01)

Silybin Cocrystals with Improved Solubility and Bioavailability
حسب: Bingqing Zhu, وآخرون
منشور في: (2025-01-01)

Salicylic acid increases flavonolignans accumulation in the fruits of hydroponically cultured Silybum marianum
حسب: Hayam S. Ahmed, وآخرون
منشور في: (2020-05-01)

Anti-Inflammatory Flavonolignans from <i>Triticum aestivum</i> Linn. Hull
حسب: Ah-Reum Han, وآخرون
منشور في: (2020-12-01)

Expert Opinion on the Management of Non-Alcoholic Fatty Liver Disease (NAFLD) in the Middle East with a Focus on the Use of Silymarin
حسب: Ahmed Hashem, وآخرون
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Cancer chemoprevention through dietary flavonoids: what’s limiting?
حسب: Haneen Amawi, وآخرون
منشور في: (2017-06-01)

Core Structure–Activity Relationship Studies of 5,7,20-<i>O</i>-Trimethylsilybins in Prostate Cancer Cell Models
حسب: Sitong Wu, وآخرون
منشور في: (2023-04-01)

Dual SMO/BRAF Inhibition by Flavonolignans from <i>Silybum marianum</i>
حسب: Antonia Diukendjieva, وآخرون
منشور في: (2020-05-01)

A Comprehensive Review on the Antibacterial, Antifungal, Antiviral, and Antiparasitic Potential of Silybin
حسب: José Lima Pereira-Filho, وآخرون
منشور في: (2024-11-01)

Influence of irrigation and row spacing on the growth, seed yield and active substance of milk thistle (Silybum marianum)
حسب: G. Karimzedah, وآخرون
منشور في: (2001-09-01)