SPP1+ macrophages promote head and neck squamous cell carcinoma progression by secreting TNF-α and IL-1β

Abstract Background Head and neck squamous cell carcinoma (HNSCC) is a very aggressive disease characterized by a heterogeneous tumor immune microenvironment (TIME). Tumor-associated macrophages (TAMs) constitute the major innate immune population in the TIME where they facilitate crucial regulatory...

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Bibliographic Details
Published in:Journal of Experimental & Clinical Cancer Research
Main Authors: Chun Liu, Kun Wu, Chuwen Li, Zhen Zhang, Peisong Zhai, Haiyan Guo, Jianjun Zhang
Format: Article
Language:English
Published: BMC 2024-12-01
Subjects:
Macrophages
Single-cell RNA sequencing
SPP1 + macrophages
TNF-α; IL-1β
Online Access:https://doi.org/10.1186/s13046-024-03255-w

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