Micro-Nano Bioactive Glass Particles Incorporated Porous Scaffold for Promoting Osteogenesis and Angiogenesis in vitro
Constructing the interconnected porous biomaterials scaffolds with osteogenesis and angiogenesis capacity is extremely important for efficient bone tissue engineering. Herein, we fabricated a bioactive micro-nano composite scaffolds with excellent in vitro osteogenesis and angiogenesis capacity, bas...
| Published in: | Frontiers in Chemistry |
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| Main Authors: | , , , , , , , , |
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2019-03-01
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| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fchem.2019.00186/full |
| _version_ | 1856999791621308416 |
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| author | Ting Tian Ting Tian Ting Tian Weihan Xie Weihan Xie Weihan Xie Wendong Gao Wendong Gao Wendong Gao Gang Wang Gang Wang Gang Wang Lei Zeng Lei Zeng Lei Zeng Guohou Miao Bo Lei Zhanyi Lin Zhanyi Lin Xiaofeng Chen Xiaofeng Chen Xiaofeng Chen |
| author_facet | Ting Tian Ting Tian Ting Tian Weihan Xie Weihan Xie Weihan Xie Wendong Gao Wendong Gao Wendong Gao Gang Wang Gang Wang Gang Wang Lei Zeng Lei Zeng Lei Zeng Guohou Miao Bo Lei Zhanyi Lin Zhanyi Lin Xiaofeng Chen Xiaofeng Chen Xiaofeng Chen |
| author_sort | Ting Tian |
| collection | DOAJ |
| container_title | Frontiers in Chemistry |
| description | Constructing the interconnected porous biomaterials scaffolds with osteogenesis and angiogenesis capacity is extremely important for efficient bone tissue engineering. Herein, we fabricated a bioactive micro-nano composite scaffolds with excellent in vitro osteogenesis and angiogenesis capacity, based on poly (lactic-co-glycolic acid) (PLGA) incorporated with micro-nano bioactive glass (MNBG). The results showed that the addition of MNBG enlarged the pore size, increased the compressive modulus (4 times improvement), enhanced the physiological stability and apatite-forming ability of porous PLGA scaffolds. The in vitro studies indicated that the PLGA-MNBG porous scaffold could enhance the mouse bone mesenchymal stem cells (mBMSCs) attachment, proliferation, and promote the expression of osteogenesis marker (ALP). Additionally, PLGA-MNBG could also support the attachment and proliferation of human umbilical vein endothelial cells (HUVECs), and significantly enhanced the expression of angiogenesis marker (CD31) of HUVECs. The as-prepared bioactive PLGA-MNBG nanocomposites scaffolds with good osteogenesis and angiogenesis probably have a promising application for bone tissue regeneration. |
| format | Article |
| id | doaj-art-4ff32fa06cee454994fbf6bcfdc6f8cb |
| institution | Directory of Open Access Journals |
| issn | 2296-2646 |
| language | English |
| publishDate | 2019-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| spelling | doaj-art-4ff32fa06cee454994fbf6bcfdc6f8cb2025-08-19T19:50:29ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462019-03-01710.3389/fchem.2019.00186437580Micro-Nano Bioactive Glass Particles Incorporated Porous Scaffold for Promoting Osteogenesis and Angiogenesis in vitroTing Tian0Ting Tian1Ting Tian2Weihan Xie3Weihan Xie4Weihan Xie5Wendong Gao6Wendong Gao7Wendong Gao8Gang Wang9Gang Wang10Gang Wang11Lei Zeng12Lei Zeng13Lei Zeng14Guohou Miao15Bo Lei16Zhanyi Lin17Zhanyi Lin18Xiaofeng Chen19Xiaofeng Chen20Xiaofeng Chen21Guangzhou Higher Education Mega Center, School of Medicine, South China University of Technology, Guangzhou, ChinaDepartment of Biomedical Engineering, School of Materials Science and Engineering, South China University of Technology, Guangzhou, ChinaNational Engineering Research Center for Tissue Restoration and Reconstruction, Guangzhou, ChinaDepartment of Biomedical Engineering, School of Materials Science and Engineering, South China University of Technology, Guangzhou, ChinaNational Engineering Research Center for Tissue Restoration and Reconstruction, Guangzhou, ChinaKey Laboratory of Biomedical Materials and Engineering, South China University of Technology, Ministry of Education, Guangzhou, ChinaDepartment of Biomedical Engineering, School of Materials Science and Engineering, South China University of Technology, Guangzhou, ChinaNational Engineering Research Center for Tissue Restoration and Reconstruction, Guangzhou, ChinaKey Laboratory of Biomedical Materials and Engineering, South China University of Technology, Ministry of Education, Guangzhou, ChinaDepartment of Biomedical Engineering, School of Materials Science and Engineering, South China University of Technology, Guangzhou, ChinaNational Engineering Research Center for Tissue Restoration and Reconstruction, Guangzhou, ChinaKey Laboratory of Biomedical Materials and Engineering, South China University of Technology, Ministry of Education, Guangzhou, ChinaDepartment of Biomedical Engineering, School of Materials Science and Engineering, South China University of Technology, Guangzhou, ChinaNational Engineering Research Center for Tissue Restoration and Reconstruction, Guangzhou, ChinaKey Laboratory of Biomedical Materials and Engineering, South China University of Technology, Ministry of Education, Guangzhou, ChinaKey Laboratory of Oral Medicine, Guangzhou Institute of Oral Disease, Stomatology Hospital of Guangzhou Medical University, Guangzhou, ChinaInstrument Analysis Center, Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, ChinaGuangzhou Higher Education Mega Center, School of Medicine, South China University of Technology, Guangzhou, ChinaDepartment of Cardiology, Guangdong General Hospital, School of Medicine, South China University of Technology, Guangdong, ChinaDepartment of Biomedical Engineering, School of Materials Science and Engineering, South China University of Technology, Guangzhou, ChinaNational Engineering Research Center for Tissue Restoration and Reconstruction, Guangzhou, ChinaKey Laboratory of Biomedical Materials and Engineering, South China University of Technology, Ministry of Education, Guangzhou, ChinaConstructing the interconnected porous biomaterials scaffolds with osteogenesis and angiogenesis capacity is extremely important for efficient bone tissue engineering. Herein, we fabricated a bioactive micro-nano composite scaffolds with excellent in vitro osteogenesis and angiogenesis capacity, based on poly (lactic-co-glycolic acid) (PLGA) incorporated with micro-nano bioactive glass (MNBG). The results showed that the addition of MNBG enlarged the pore size, increased the compressive modulus (4 times improvement), enhanced the physiological stability and apatite-forming ability of porous PLGA scaffolds. The in vitro studies indicated that the PLGA-MNBG porous scaffold could enhance the mouse bone mesenchymal stem cells (mBMSCs) attachment, proliferation, and promote the expression of osteogenesis marker (ALP). Additionally, PLGA-MNBG could also support the attachment and proliferation of human umbilical vein endothelial cells (HUVECs), and significantly enhanced the expression of angiogenesis marker (CD31) of HUVECs. The as-prepared bioactive PLGA-MNBG nanocomposites scaffolds with good osteogenesis and angiogenesis probably have a promising application for bone tissue regeneration.https://www.frontiersin.org/article/10.3389/fchem.2019.00186/fullbioactive glassmicro-nano particlesnanocomposites scaffoldsbone regenerationosteogenesis |
| spellingShingle | Ting Tian Ting Tian Ting Tian Weihan Xie Weihan Xie Weihan Xie Wendong Gao Wendong Gao Wendong Gao Gang Wang Gang Wang Gang Wang Lei Zeng Lei Zeng Lei Zeng Guohou Miao Bo Lei Zhanyi Lin Zhanyi Lin Xiaofeng Chen Xiaofeng Chen Xiaofeng Chen Micro-Nano Bioactive Glass Particles Incorporated Porous Scaffold for Promoting Osteogenesis and Angiogenesis in vitro bioactive glass micro-nano particles nanocomposites scaffolds bone regeneration osteogenesis |
| title | Micro-Nano Bioactive Glass Particles Incorporated Porous Scaffold for Promoting Osteogenesis and Angiogenesis in vitro |
| title_full | Micro-Nano Bioactive Glass Particles Incorporated Porous Scaffold for Promoting Osteogenesis and Angiogenesis in vitro |
| title_fullStr | Micro-Nano Bioactive Glass Particles Incorporated Porous Scaffold for Promoting Osteogenesis and Angiogenesis in vitro |
| title_full_unstemmed | Micro-Nano Bioactive Glass Particles Incorporated Porous Scaffold for Promoting Osteogenesis and Angiogenesis in vitro |
| title_short | Micro-Nano Bioactive Glass Particles Incorporated Porous Scaffold for Promoting Osteogenesis and Angiogenesis in vitro |
| title_sort | micro nano bioactive glass particles incorporated porous scaffold for promoting osteogenesis and angiogenesis in vitro |
| topic | bioactive glass micro-nano particles nanocomposites scaffolds bone regeneration osteogenesis |
| url | https://www.frontiersin.org/article/10.3389/fchem.2019.00186/full |
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