Modeling CADASIL vascular pathologies with patient-derived induced pluripotent stem cells

Abstract Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a rare hereditary cerebrovascular disease caused by a NOTCH3 mutation. However, the underlying cellular and molecular mechanisms remain unidentified. Here, we generated non-integrative in...

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Bibliographic Details
Published in:Protein & Cell
Main Authors: Chen Ling, Zunpeng Liu, Moshi Song, Weiqi Zhang, Si Wang, Xiaoqian Liu, Shuai Ma, Shuhui Sun, Lina Fu, Qun Chu, Juan Carlos Izpisua Belmonte, Zhaoxia Wang, Jing Qu, Yun Yuan, Guang-Hui Liu
Format: Article
Language:English
Published: Oxford University Press 2019-02-01
Subjects:
CADASIL
iPSC
NOTCH
NF-κB
vascular smooth muscle
Online Access:http://link.springer.com/article/10.1007/s13238-019-0608-1

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