Causal relationship between lipid-lowering drugs and ovarian cancer, cervical cancer: a drug target mendelian randomization study
Abstract Background The causal impact of lipid-lowering drugs on ovarian cancer (OC) and cervical cancer (CC) has received considerable attention, but its causal relationship is still a subject of debate. Hence, the objective of this study is to evaluate the impact of lipid-lowering medications on t...
| Published in: | BMC Cancer |
|---|---|
| Main Authors: | Jinshuai Li, Zixian Yang, Tao Wang, Mengqi Li, Xiangjian Wu, Xiaoyan Fu, Chunfeng Yang, Yangpu Li, Ximing Wang, Zhiming Lan, Minfang Li, Sheng Chen |
| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-05-01
|
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12885-024-12434-z |
Similar Items
Causal relationship between PCSK9 inhibitor and common neurodegenerative diseases: A drug target Mendelian randomization study
by: Qiang Huang, et al.
Published: (2024-06-01)
by: Qiang Huang, et al.
Published: (2024-06-01)
Causal relationship between PCSK9 inhibitor and autoimmune diseases: a drug target Mendelian randomization study
by: Weijia Xie, et al.
Published: (2023-08-01)
by: Weijia Xie, et al.
Published: (2023-08-01)
PCSK9 inhibitors and osteoporosis: mendelian randomization and meta-analysis
by: Ding-Qiang Chen, et al.
Published: (2024-07-01)
by: Ding-Qiang Chen, et al.
Published: (2024-07-01)
Causal relationship between PCSK9 inhibitor and primary glomerular disease: a drug target Mendelian randomization study
by: Hangyu Duan, et al.
Published: (2024-03-01)
by: Hangyu Duan, et al.
Published: (2024-03-01)
Association of lipid-lowering drugs with risk of sarcopenia: a drug target mendelian randomization study and meta-analysis
by: Jiaxin Li, et al.
Published: (2024-07-01)
by: Jiaxin Li, et al.
Published: (2024-07-01)
Assessing the safety of lipid-modifying medications among Chinese adolescents: a drug-target Mendelian randomization study
by: Shan Luo, et al.
Published: (2023-10-01)
by: Shan Luo, et al.
Published: (2023-10-01)
Lipid-lowering drugs and risk of rapid renal function decline: a mendelian randomization study
by: Zhicheng Zhao, et al.
Published: (2024-10-01)
by: Zhicheng Zhao, et al.
Published: (2024-10-01)
Mendelian Randomized Study of Protective Effect of Statins on Breast Cancer
by: Di HU, et al.
Published: (2025-02-01)
by: Di HU, et al.
Published: (2025-02-01)
HMG-Coenzyme A Reductase as a Drug Target for the Prevention of Ankylosing Spondylitis
by: Zhenyu Zhong, et al.
Published: (2021-10-01)
by: Zhenyu Zhong, et al.
Published: (2021-10-01)
Can Lipid-Lowering Drugs Reduce the Risk of Cholelithiasis? A Mendelian Randomization Study
by: Dong H, et al.
Published: (2024-02-01)
by: Dong H, et al.
Published: (2024-02-01)
Cholesterol confers resistance to Apatinib-mediated ferroptosis in gastric cancer
by: Zhiwei Li, et al.
Published: (2025-07-01)
by: Zhiwei Li, et al.
Published: (2025-07-01)
SIAH1 ubiquitination-modified HMGCR inhibits lung cancer progression and promotes drug sensitivity through cholesterol synthesis
by: Hongmei Yuan, et al.
Published: (2023-04-01)
by: Hongmei Yuan, et al.
Published: (2023-04-01)
Comprehensive Mendelian randomization analysis of low-density lipoprotein cholesterol and multiple cancers
by: Hengchang Liang, et al.
Published: (2024-12-01)
by: Hengchang Liang, et al.
Published: (2024-12-01)
COPD and T2DM: a Mendelian randomization study
by: Tao Wang, et al.
Published: (2024-02-01)
by: Tao Wang, et al.
Published: (2024-02-01)
LDL Receptor Pathway Regulation by miR-224 and miR-520d
by: Alessandro G. Salerno, et al.
Published: (2020-05-01)
by: Alessandro G. Salerno, et al.
Published: (2020-05-01)
High expression of RUNX1 in colorectal cancer subtype accelerates malignancy by inhibiting HMGCR
by: Zhilin Chang, et al.
Published: (2024-08-01)
by: Zhilin Chang, et al.
Published: (2024-08-01)
PCSK9 inhibition and broad health outcomes: A Mendelian randomization phenome‑wide association study
by: Kai Zhang, et al.
Published: (2024-05-01)
by: Kai Zhang, et al.
Published: (2024-05-01)
Genetically proxied therapeutic effect of antihypertensive drug use, breast cancer, and ovarian cancer’s risk: a drug-target Mendelian randomization study
by: Chunxiao Dang, et al.
Published: (2025-07-01)
by: Chunxiao Dang, et al.
Published: (2025-07-01)
A causality between fruit consumption and colorectal cancer: a two-sample Mendelian randomization analysis
by: Li Yang
Published: (2024-03-01)
by: Li Yang
Published: (2024-03-01)
Exploring the causal role of plasma metabolites and metabolite ratios in prostate cancer: a two-sample Mendelian randomization study
by: Changzhou Feng, et al.
Published: (2025-01-01)
by: Changzhou Feng, et al.
Published: (2025-01-01)
Effects of genetically proxied statins on diabetic nephropathy and retinopathy: a Mendelian randomization study
by: Ran Zhao, et al.
Published: (2024-07-01)
by: Ran Zhao, et al.
Published: (2024-07-01)
Drug repositioning and ovarian cancer, a study based on Mendelian randomisation analysis
by: Lin Zhu, et al.
Published: (2024-04-01)
by: Lin Zhu, et al.
Published: (2024-04-01)
The Potential Therapeutic Applications of Natural Products in the Oxidative Stress-Related MVA Pathway: Focus on HMGCR
by: Yu-Ning Teng
Published: (2025-08-01)
by: Yu-Ning Teng
Published: (2025-08-01)
Association of lipid-lowering drugs with the risk of type 2 diabetes and its complications: a mendelian randomized study
by: Yue-Yang Zhang, et al.
Published: (2024-10-01)
by: Yue-Yang Zhang, et al.
Published: (2024-10-01)
Statins as a risk factor for diabetic retinopathy: a Mendelian randomization and cross-sectional observational study
by: Chengming Chen, et al.
Published: (2024-03-01)
by: Chengming Chen, et al.
Published: (2024-03-01)
The causal relationship between anti-CD20 antibodies and endometrial cancer: a Mendelian randomization study
by: Jinqiu Su, et al.
Published: (2024-11-01)
by: Jinqiu Su, et al.
Published: (2024-11-01)
Causal relationship between immune cell signatures and colorectal cancer: a bi-directional, two-sample mendelian randomization study
by: Ruizhi Liu, et al.
Published: (2025-03-01)
by: Ruizhi Liu, et al.
Published: (2025-03-01)
Educational attainment and endometrial cancer: A Mendelian randomization study
by: Qixia Wang, et al.
Published: (2022-11-01)
by: Qixia Wang, et al.
Published: (2022-11-01)
Serum PCSK9 is a novel serological biomarker for the diagnosis and prognosis of pancreatic cancer
by: Ying Xu, et al.
Published: (2024-09-01)
by: Ying Xu, et al.
Published: (2024-09-01)
Causal association between modifiable risk factors and esophageal cancer: A Mendelian randomization study
by: Xiaoqing Wang, et al.
Published: (2025-07-01)
by: Xiaoqing Wang, et al.
Published: (2025-07-01)
Case report: Rapid clinical improvement of anti-HMGCR immune-mediated necrotizing myopathy treated with efgartigimod
by: Quantao Zeng, et al.
Published: (2024-11-01)
by: Quantao Zeng, et al.
Published: (2024-11-01)
Causal association between mitochondrial genes and colorectal cancer: a multi-omics Mendelian randomization study
by: Zhandong Zhang, et al.
Published: (2025-10-01)
by: Zhandong Zhang, et al.
Published: (2025-10-01)
Exploring the causal effect between lipid-modifying drugs and idiopathic pulmonary fibrosis: a drug-target Mendelian randomization study
by: Gexiang Cai, et al.
Published: (2024-08-01)
by: Gexiang Cai, et al.
Published: (2024-08-01)
Identifying causal relationships between 35 blood and urine biomarkers and urologic cancers: MR-meta combined with Bayesian colocalization Mendelian randomization analysis
by: Wenxin An, et al.
Published: (2024-11-01)
by: Wenxin An, et al.
Published: (2024-11-01)
The association between circulatory, local pancreatic PCSK9 and type 2 diabetes mellitus: The effects of antidiabetic drugs on PCSK9
by: Fengyuan Lu, et al.
Published: (2023-09-01)
by: Fengyuan Lu, et al.
Published: (2023-09-01)
Evidence of the association between asthma and lung cancer risk from mendelian randomization analysis
by: Lingling Ye, et al.
Published: (2024-10-01)
by: Lingling Ye, et al.
Published: (2024-10-01)
Genetic evidence implicating circulating lipids and lipid drug targets in pterygium
by: Yuchen Cai, et al.
Published: (2023-01-01)
by: Yuchen Cai, et al.
Published: (2023-01-01)
Discovery of an orally active VHL-recruiting PROTAC that achieves robust HMGCR degradation and potent hypolipidemic activity in vivo
by: Guoshun Luo, et al.
Published: (2021-05-01)
by: Guoshun Luo, et al.
Published: (2021-05-01)
The causal relationship between antihypertensive drugs and depression: a Mendelian randomization study of drug targets
by: Zixian Yang, et al.
Published: (2024-08-01)
by: Zixian Yang, et al.
Published: (2024-08-01)
Identification and validation of PCSK9 as a prognostic and immune-related influencing factor in tumorigenesis: a pan-cancer analysis
by: Chao Sun, et al.
Published: (2023-10-01)
by: Chao Sun, et al.
Published: (2023-10-01)
Similar Items
-
Causal relationship between PCSK9 inhibitor and common neurodegenerative diseases: A drug target Mendelian randomization study
by: Qiang Huang, et al.
Published: (2024-06-01) -
Causal relationship between PCSK9 inhibitor and autoimmune diseases: a drug target Mendelian randomization study
by: Weijia Xie, et al.
Published: (2023-08-01) -
PCSK9 inhibitors and osteoporosis: mendelian randomization and meta-analysis
by: Ding-Qiang Chen, et al.
Published: (2024-07-01) -
Causal relationship between PCSK9 inhibitor and primary glomerular disease: a drug target Mendelian randomization study
by: Hangyu Duan, et al.
Published: (2024-03-01) -
Association of lipid-lowering drugs with risk of sarcopenia: a drug target mendelian randomization study and meta-analysis
by: Jiaxin Li, et al.
Published: (2024-07-01)
