Early echocardiographic alterations in cancer patients during chemotherapy

• 出版年: Российский кардиологический журнал
• 主要な著者: Z. Z.A. Fashafsha, P. Sh. Chomakhidze, D. F. Mesitskaya, A. Yu. Suvorov, M. I. Sekacheva, E. V. Poddubskaya, E. S. Tyukanova, M. V. Sankova, M. A. Ozova, V. D. Levina, D. А. Andreev, F. Yu. Kopylov
• フォーマット: 論文
• 言語: ロシア語
• 出版事項: «FIRMA «SILICEA» LLC 2022-12-01
• 主題: cardiotoxicity; myocardial dysfunction; left ventricular ejection fraction; global longitudinal strain
• オンライン･アクセス: https://russjcardiol.elpub.ru/jour/article/view/5093
• ISSN: 1560-4071; 2618-7620

Aim. To evaluate the early manifestation of cardiotoxicity after the first course of multiagent chemotherapy (MAC) using echocardiography with an assessment of the left ventricular ejection fraction (LVEF) and global longitudinal strain (GLS).Material and methods. The study included 49 cancer patients with elective MAC.Results. After the first administration of a therapeutic dose of chemotherapy, a decrease in LVEF ≥10 and GLS >15 was demonstrated in more than 6,1% of patients, as well as a subclinical decrease in LVEF ≥5% in 22,4% and a decrease in GLS ≥12% in 24,5%.Conclusion. In cancer patients, after the first course of chemotherapy, GLS dynamics should be assessed during echocardiography as a marker of myocardial dysfunction.