A Review of the Role of Stereotactic Radiosurgery and Immunotherapy in the Management of Primary Central Nervous System Tumors

Stereotactic radiosurgery (SRS) and immune checkpoint inhibitors (ICIs) are widely used in the management of brain metastases. These therapies are commonly administered concurrently; as SRS may enhance anti-tumor immunity and responsiveness to ICIs. However, the use of ICIs with and without SRS in t...

Full description

Bibliographic Details
Published in:	Biomedicines
Main Authors:	Eric J. Lehrer, Brianna M. Jones, Kunal K. Sindhu, Daniel R. Dickstein, Mira Cohen, Stanislav Lazarev, Alfredo Quiñones-Hinojosa, Sheryl Green, Daniel M. Trifiletti
Format:	Article
Language:	English
Published:	MDPI AG 2022-11-01
Subjects:	stereotactic radiosurgery immunotherapy neurosurgery radiation oncology glioma meningioma
Online Access:	https://www.mdpi.com/2227-9059/10/11/2977

Similar Items

Preoperative Stereotactic Radiosurgery for Glioblastoma
by: Eric J. Lehrer, et al.
Published: (2022-01-01)

Orbital meningioma treated by stereotactic radiosurgery
by: Dong-fang Wu, et al.
Published: (2023-10-01)

Robotic stereotactic radiosurgery for intracranial meningiomas in elderly patients: assessment of treatment efficacy and safety
by: Anton Früh, et al.
Published: (2024-01-01)

A Pathophysiological Approach to Reduce Peritumoral Edema with Gamma Knife Radiosurgery for Large Incidental Meningiomas
by: Cheng-Siu Chang, et al.
Published: (2022-10-01)

Combined helical tomotherapy and Gamma Knife stereotactic radiosurgery for high-grade recurrent orbital meningioma: a case report
by: Haomiao Zhang, et al.
Published: (2023-10-01)

Surgical Resection Followed by Stereotactic Radiosurgery (S+SRS) Versus SRS Alone for Large Posterior Fossa Brain Metastases: A Comparative Analysis of Outcomes and Factors Guiding Treatment Modality Selection
by: Ruth Lau, et al.
Published: (2024-10-01)

Stereotactic radiosurgery and radiotherapy in complex treatment of patients with intracranial pilocytic astrocytomas
by: Yury Yu. Trunin, et al.
Published: (2023-05-01)

The Efficacy and Tolerability of Radiosurgery in Treating Benign Meningiomas: A Dose Comparison Study from a Single-Center Analysis
by: Hyun-Jeong Cho, et al.
Published: (2024-05-01)

Editorial: Aspiring for onco-functional utopia via radiosurgery
by: Harsh Deora, et al.
Published: (2023-05-01)

The Role of Stereotactic Radiosurgery in the Treatment of Large Brain Metastases
by: O. L. Evdokimova, et al.
Published: (2022-10-01)

SAFESTEREO: phase II randomized trial to compare stereotactic radiosurgery with fractionated stereotactic radiosurgery for brain metastases
by: J. A. Crouzen, et al.
Published: (2023-03-01)

Stereotactic Radiosurgery in the Complex Treatment of Patients With Epilepsy Associated With Various Structural Brain Lesions
by: V. V. Krylov, et al.
Published: (2021-04-01)

ZAP-X Radiosurgery: First experience of 50 consecutive cases in Korea
by: In-Ho Jung, et al.
Published: (2025-06-01)

Technical note: Image guided internal fiducial placement for stereotactic radiosurgery (CyberKnife)
by: Govindarajan Janardan Mallarajapatna, et al.
Published: (2011-01-01)

Understanding the Radiobiology of Central Nervous System Diseases in the Golden Age of Radiosurgery—Does It Matter?
by: Fred C. Lam, et al.
Published: (2025-06-01)

Reirradiation with stereotactic radiosurgery for vestibular schwannomas – a systematic review and meta-analysis
by: Noel-Adrian Hollosi, et al.
Published: (2025-09-01)

Stereotactic radiosurgery for treatment resistant depression: Systematic review
by: Jordan Vanleuven, et al.
Published: (2025-04-01)

Linac-based stereotactic radiosurgery for brain arteriovenous malformations
by: Ahmed Gawish, et al.
Published: (2022-09-01)

Outcomes and predictive factors after second stereotactic radiosurgery for refractory trigeminal neuralgia
by: Bailey A. Loving, et al.
Published: (2025-07-01)

STEREOTACTIC RADIOTHERAPY AND RADIOSURGERY IN THE TREATMENT OF PATIENTS WITH BRAIN PILOID ASTROCYTOMAS OF DEEP LOCATION
by: Yu. Yu. Trunin, et al.
Published: (2015-04-01)

Gamma Knife stereotactic radiosurgery for intraocular retinoblastoma: a 5-year experience
by: A. A. Yarovoy, et al.
Published: (2021-04-01)

Stereotactic radiosurgery of brain metastases: a retrospective study
by: Isabella Gruber, et al.
Published: (2023-12-01)

Stereotactic radiosurgery for brain metastases from non-uterine Leiomyosarcoma: A retrospective case series
by: Juan J. Cardona, et al.
Published: (2025-10-01)

Should post-operative stereotactic radiosurgery be the standard of care in Craniopharyngioma patients?
by: Saurabh Gupta, et al.
Published: (2024-04-01)

What if: A retrospective reconstruction of resection cavity stereotactic radiosurgery to mimic neoadjuvant stereotactic radiosurgery
by: Gueliz Acker, et al.
Published: (2023-03-01)

Machine learning-based models in prediction of the radiological outcomes of vestibular schwannoma following stereotactic radiosurgery: a systematic review and meta-analysis
by: Bardia Hajikarimloo, et al.
Published: (2025-09-01)

Corrigendum: What if: a retrospective reconstruction of resection cavity stereotactic radiosurgery to mimic neoadjuvant stereotactic radiosurgery
by: Gueliz Acker, et al.
Published: (2023-08-01)

Early Results of Stereotactic Radiosurgery in Uveal Melanoma and Risk Factors for Radiation Retinopathy
by: Gökçen Özcan, et al.
Published: (2020-06-01)

Stereotactic radiosurgery for brain metastases in a child with extra-skeletal Ewing's sarcoma
by: T. S. Rogova, et al.
Published: (2022-09-01)

The efficacy of surgery over stereotactic radiosurgery in the management of tumor-related trigeminal neuralgia
by: Alexander Abouharb, et al.
Published: (2024-10-01)

Glossopharyngeal neuralgia treated using stereotactic Gamma Knife radiosurgery
by: Ping-Hsien Hsieh, et al.
Published: (2019-01-01)

The specifics in the work of a nurse on stereotactic radiosurgery - gamma knife
by: Novaković Momčilo, et al.
Published: (2019-01-01)

Role of Radiosurgery/Stereotactic Radiotherapy in Oligometastatic Disease: Brain Oligometastases
by: Rosario Mazzola, et al.
Published: (2019-04-01)

Stereotactic radiosurgery for idiopathic glossopharyngeal neuralgia: A systematic review
by: Timoleon Siempis, et al.
Published: (2024-04-01)

Overall survival following stereotactic radiosurgery for ten or more brain metastases: a systematic review and meta-analysis
by: Hamoun Rozati, et al.
Published: (2023-10-01)

Treatment of metastatic breast cancer by stereotactic body radiotherapy (SBRT) and stereotactic radiosurgery (SRS)
by: Xiaomin Li, et al.
Published: (2024-12-01)

Stereotactic radiosurgery for Nelson's syndrome: A meta-analysis and systematic review of clinical outcomes
by: Yang Wu, et al.
Published: (2022-03-01)

Survival after Stereotactic Radiosurgery in the Era of Targeted Therapy: Number of Metastases No Longer Matters
by: James de Boisanger, et al.
Published: (2024-05-01)

Fractionated Stereotactic Radiation for Central Nervous System Lymphoma: Retrospective Analysis of Initial Cases
by: Daniel G. Schep, et al.
Published: (2023-09-01)

Neoadjuvant stereotactic radiosurgery for brain metastases: Current evidence and clinical perspectives
by: Aybala Nur Ucgul, et al.
Published: (2025-09-01)