Recent advances in research on aspartate β-hydroxylase (ASPH) in pancreatic cancer: A brief update
Pancreatic cancer (PC) is a highly aggressive tumor, often difficult to diagnose and treat. Aspartate β-hydroxylase (ASPH) is a type II transmembrane protein and the member of α-ketoglutarate-dependent dioxygenase family, found to be overexpressed in different cancer types, including PC. ASPH appear...
| الحاوية / القاعدة: | Biomolecules & Biomedicine |
|---|---|
| المؤلفون الرئيسيون: | , , , , , , |
| التنسيق: | مقال |
| اللغة: | الإنجليزية |
| منشور في: |
Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
2018-11-01
|
| الموضوعات: | |
| الوصول للمادة أونلاين: | https://www.bjbms.org/ojs/index.php/bjbms/article/view/3539 |
| _version_ | 1850274718347689984 |
|---|---|
| author | Guofang Hou Boran Xu Yanghui Bi Chuanlin Wu Beibei Ru Bei Sun Xuewei Bai |
| author_facet | Guofang Hou Boran Xu Yanghui Bi Chuanlin Wu Beibei Ru Bei Sun Xuewei Bai |
| author_sort | Guofang Hou |
| collection | DOAJ |
| container_title | Biomolecules & Biomedicine |
| description | Pancreatic cancer (PC) is a highly aggressive tumor, often difficult to diagnose and treat. Aspartate β-hydroxylase (ASPH) is a type II transmembrane protein and the member of α-ketoglutarate-dependent dioxygenase family, found to be overexpressed in different cancer types, including PC. ASPH appears to be involved in the regulation of proliferation, invasion and metastasis of PC cells through multiple signaling pathways, suggesting its role as a tumor biomarker and therapeutic target. In this review, we briefly summarize the possible mechanisms of action of ASPH in PC and recent progress in the therapeutic approaches targeting ASPH.
|
| format | Article |
| id | doaj-art-56befd0fbdc34eefbd258f4888dcf0b3 |
| institution | Directory of Open Access Journals |
| issn | 2831-0896 2831-090X |
| language | English |
| publishDate | 2018-11-01 |
| publisher | Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina |
| record_format | Article |
| spelling | doaj-art-56befd0fbdc34eefbd258f4888dcf0b32025-08-19T23:41:29ZengAssociation of Basic Medical Sciences of Federation of Bosnia and HerzegovinaBiomolecules & Biomedicine2831-08962831-090X2018-11-0118410.17305/bjbms.2018.3539Recent advances in research on aspartate β-hydroxylase (ASPH) in pancreatic cancer: A brief updateGuofang Hou0Boran Xu1Yanghui Bi2Chuanlin Wu3Beibei Ru4Bei Sun5Xuewei Bai6Department of Pancreatic and Biliary Surgery, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, ChinaDepartment of Pancreatic and Biliary Surgery, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, ChinaDepartment of Pathology and Pathophysiology, Capital Medical University, Beijing, ChinaDepartment of Pancreatic and Biliary Surgery, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, ChinaDepartment of Pancreatic and Biliary Surgery, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, ChinaDepartment of Pancreatic and Biliary Surgery, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, ChinaDepartment of Pancreatic and Biliary Surgery, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, ChinaPancreatic cancer (PC) is a highly aggressive tumor, often difficult to diagnose and treat. Aspartate β-hydroxylase (ASPH) is a type II transmembrane protein and the member of α-ketoglutarate-dependent dioxygenase family, found to be overexpressed in different cancer types, including PC. ASPH appears to be involved in the regulation of proliferation, invasion and metastasis of PC cells through multiple signaling pathways, suggesting its role as a tumor biomarker and therapeutic target. In this review, we briefly summarize the possible mechanisms of action of ASPH in PC and recent progress in the therapeutic approaches targeting ASPH. https://www.bjbms.org/ojs/index.php/bjbms/article/view/3539Aspartate β-hydroxylasepancreatic cancerNotch signaling pathwayMitochondrial DNANK cell |
| spellingShingle | Guofang Hou Boran Xu Yanghui Bi Chuanlin Wu Beibei Ru Bei Sun Xuewei Bai Recent advances in research on aspartate β-hydroxylase (ASPH) in pancreatic cancer: A brief update Aspartate β-hydroxylase pancreatic cancer Notch signaling pathway Mitochondrial DNA NK cell |
| title | Recent advances in research on aspartate β-hydroxylase (ASPH) in pancreatic cancer: A brief update |
| title_full | Recent advances in research on aspartate β-hydroxylase (ASPH) in pancreatic cancer: A brief update |
| title_fullStr | Recent advances in research on aspartate β-hydroxylase (ASPH) in pancreatic cancer: A brief update |
| title_full_unstemmed | Recent advances in research on aspartate β-hydroxylase (ASPH) in pancreatic cancer: A brief update |
| title_short | Recent advances in research on aspartate β-hydroxylase (ASPH) in pancreatic cancer: A brief update |
| title_sort | recent advances in research on aspartate β hydroxylase asph in pancreatic cancer a brief update |
| topic | Aspartate β-hydroxylase pancreatic cancer Notch signaling pathway Mitochondrial DNA NK cell |
| url | https://www.bjbms.org/ojs/index.php/bjbms/article/view/3539 |
| work_keys_str_mv | AT guofanghou recentadvancesinresearchonaspartatebhydroxylaseasphinpancreaticcancerabriefupdate AT boranxu recentadvancesinresearchonaspartatebhydroxylaseasphinpancreaticcancerabriefupdate AT yanghuibi recentadvancesinresearchonaspartatebhydroxylaseasphinpancreaticcancerabriefupdate AT chuanlinwu recentadvancesinresearchonaspartatebhydroxylaseasphinpancreaticcancerabriefupdate AT beibeiru recentadvancesinresearchonaspartatebhydroxylaseasphinpancreaticcancerabriefupdate AT beisun recentadvancesinresearchonaspartatebhydroxylaseasphinpancreaticcancerabriefupdate AT xueweibai recentadvancesinresearchonaspartatebhydroxylaseasphinpancreaticcancerabriefupdate |