Phase I trial of an alhydrogel adjuvanted hepatitis B core virus-like particle containing epitopes of Plasmodium falciparum circumsporozoite protein.

<h4>Unlabelled</h4>The objectives of this non-randomized, non-blinded, dose-escalating Phase I clinical trial were to assess the safety, reactogenicity and immunogenicity of ICC-1132 formulated with Alhydrogel (aluminum hydroxide) in 51 healthy, malaria-naive adults aged 18 to 45 years....

Full description

Bibliographic Details
Published in:	PLoS ONE
Main Authors:	Aric L Gregson, Giane Oliveira, Caroline Othoro, J Mauricio Calvo-Calle, George B Thorton, Elizabeth Nardin, Robert Edelman
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2008-02-01
Online Access:	https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0001556&type=printable

Similar Items

Identification of a neutralizing epitope within minor repeat region of Plasmodium falciparum CS protein
by: J. Mauricio Calvo-Calle, et al.
Published: (2021-01-01)

T cell responses to repeat and non-repeat regions of the circumsporozoite protein detected in volunteers immunized with Plasmodium falciparum sporozoites
by: Elizabeth Nardin, et al.
Published: (1992-01-01)

Probing novel epitopes on the Plasmodium falciparum circumsporozoite protein for vaccine development
by: Pascal S. Krenger, et al.
Published: (2024-11-01)

A VLP for validation of the Plasmodium falciparum circumsporozoite protein junctional epitope for vaccine development
by: Erwan Atcheson, et al.
Published: (2021-04-01)

A multivalent Plasmodium falciparum circumsporozoite protein‐based nanoparticle malaria vaccine elicits a robust and durable antibody response against the junctional epitope and the major repeats
by: Geetanjali Pendyala, et al.
Published: (2023-07-01)

Diversity of T cell epitopes in Plasmodium falciparum circumsporozoite protein likely due to protein-protein interactions.
by: Nagesh R Aragam, et al.
Published: (2013-01-01)

Restricted valency (NPNA) n repeats and junctional epitope-based circumsporozoite protein vaccines against Plasmodium falciparum
by: Mark D. Langowski, et al.
Published: (2022-01-01)

Poly I:C elicits broader and stronger humoral and cellular responses to a Plasmodium vivax circumsporozoite protein malaria vaccine than Alhydrogel in mice
by: Tiffany B. L. Costa-Gouvea, et al.
Published: (2024-04-01)

Variation in the circumsporozoite protein of Plasmodium falciparum: vaccine development implications.
by: Kavita Gandhi, et al.
Published: (2014-01-01)

Genetic polymorphism of circumsporozoite protein of Plasmodium falciparum isolates in children in Brazzaville, Republic of Congo
by: Marcel Tapsou Baina, et al.
Published: (2025-08-01)

Genetic diversity and natural selection of circumsporozoite surface protein in Vietnam Plasmodium falciparum isolates
by: Tuấn Cường Võ, et al.
Published: (2025-10-01)

Protective effects of combining monoclonal antibodies and vaccines against the Plasmodium falciparum circumsporozoite protein.
by: Lawrence T Wang, et al.
Published: (2021-12-01)

Chimeric Plasmodium falciparum parasites expressing Plasmodium vivax circumsporozoite protein fail to produce salivary gland sporozoites
by: Catherin Marin-Mogollon, et al.
Published: (2018-08-01)

A sting in the tail—are antibodies against the C‐terminus of Plasmodium falciparum circumsporozoite protein protective?
by: Jem Murdoch, et al.
Published: (2023-04-01)

Design and Evaluation of Chimeric <i>Plasmodium falciparum</i> Circumsporozoite Protein-Based Malaria Vaccines
by: William H. Stump, et al.
Published: (2024-03-01)

Genetic variation of the Plasmodium falciparum circumsporozoite protein in parasite isolates from Homabay County in Kenya
by: Michael Maina, et al.
Published: (2024-04-01)

Genetic Diversity in the Circumsporozoite Protein Gene of Plasmodium falciparum from Major Endemic Regions of Iran
by: A Heidari, et al.
Published: (2006-07-01)

A slot blot immunoassay for quantitative detection of Plasmodium falciparum circumsporozoite protein in mosquito midgut oocyst.
by: Sanjai Kumar, et al.
Published: (2014-01-01)

Cytolytic circumsporozoite-specific memory CD4+ T cell clones are expanded during Plasmodium falciparum infection
by: Raquel Furtado, et al.
Published: (2023-11-01)

Repeat region of plasmodium falciparum circumsporozoite protein does not recognize or bind to human hepatoma target cell
by: Wayne T. Hockmeyer, et al.
Published: (1986-01-01)

Genetic polymorphism of Plasmodium falciparum circumsporozoite protein on Bioko Island, Equatorial Guinea and global comparative analysis
by: Hui-Ying Huang, et al.
Published: (2020-07-01)

Phase 1 trial of the Plasmodium falciparum blood stage vaccine MSP1(42)-C1/Alhydrogel with and without CPG 7909 in malaria naïve adults.
by: Ruth D Ellis, et al.
Published: (2010-01-01)

Molecular determinants of cross-reactivity and potency by VH3-33 antibodies against the Plasmodium falciparum circumsporozoite protein
by: Elaine Thai, et al.
Published: (2023-11-01)

Genetic polymorphism and evidence of signatures of selection in the Plasmodium falciparum circumsporozoite protein gene in Tanzanian regions with different malaria endemicity
by: Beatus M. Lyimo, et al.
Published: (2024-05-01)

Genetic polymorphism of circumsporozoite protein of Plasmodium falciparum among Chinese migrant workers returning from Africa to Henan Province
by: Zhi-quan He, et al.
Published: (2022-08-01)

Needle-free, spirulina-produced Plasmodium falciparum circumsporozoite vaccination provides sterile protection against pre-erythrocytic malaria in mice
by: Tracy Saveria, et al.
Published: (2022-10-01)

An epitope-based malaria vaccine targeting the junctional region of circumsporozoite protein
by: Lucie Jelínková, et al.
Published: (2021-01-01)

<i>Plasmodium falciparum</i> Malaria Vaccines and Vaccine Adjuvants
by: Srinivasa Reddy Bonam, et al.
Published: (2021-09-01)

The repeat region of the circumsporozoite protein is critical for sporozoite formation and maturation in Plasmodium.
by: David J P Ferguson, et al.
Published: (2014-01-01)

Comparison of major, minor and junctional circumsporozoite protein epitopes for malaria vaccine design
by: Emma Ryan, et al.
Published: (2025-10-01)

Improvement of RG1-VLP vaccine performance in BALB/c mice by substitution of alhydrogel with the next generation polyphosphazene adjuvant PCEP
by: Sarah M. Valencia, et al.
Published: (2021-08-01)

Engineered DNA-encoded monoclonal antibodies targeting Plasmodium falciparum circumsporozoite protein confer single dose protection in a murine malaria challenge model
by: Nicholas J. Tursi, et al.
Published: (2022-08-01)

Late killing of Plasmodium berghei sporozoites in the liver by an anti-circumsporozoite protein antibody
by: Manuela C Aguirre-Botero, et al.
Published: (2025-02-01)

Rationale for Further Development of a Vaccine Based on the Circumsporozoite Protein of Plasmodium vivax.
by: Anjali Yadava, et al.
Published: (2017-01-01)

Structural basis of Plasmodium vivax inhibition by antibodies binding to the circumsporozoite protein repeats
by: Iga Kucharska, et al.
Published: (2022-01-01)

Exit of Plasmodium sporozoites from oocysts is an active process that involves the circumsporozoite protein.
by: Qian Wang, et al.
Published: (2005-09-01)

Impact on malaria parasite multiplication rates in infected volunteers of the protein-in-adjuvant vaccine AMA1-C1/Alhydrogel+CPG 7909.
by: Christopher J A Duncan, et al.
Published: (2011-01-01)

Evidence for a model of conformational change by the Plasmodium falciparum circumsporozoite protein during sporozoite development in the mosquito host through the use of camelid single-domain antibodies
by: Rob Geens, et al.
Published: (2025-06-01)

Epitope-coated polymer particles elicit neutralising antibodies against Plasmodium falciparum sporozoites
by: Benjamin J. Evert, et al.
Published: (2021-11-01)

Identification of adjuvants for clinical trials performed with Plasmodium falciparum AMA1 in rabbits
by: Sumera Younis, et al.
Published: (2019-07-01)