Evaluation of six anti-SARS-CoV-2 antibody test kits and practical approaches to optimize the diagnostic performance

In an investigation of six anti-SARS-CoV-2 antibody kits with different target antigen and methodology, each kit showed comparable performance. As false-positive reactions occurred independently with different kits, specificity increased to 100% when pairs of kits were used. With three-kit combinati...

Full description

Bibliographic Details
Published in:Journal of Microbiology, Immunology and Infection
Main Authors: Jae-Hoon Ko, Eun-Jeong Joo, Jin Yang Baek, Kyungmin Huh, Sun Young Cho, Cheol-In Kang, Doo Ryeon Chung, Yae-Jean Kim, Eun-Suk Kang, Kyong Ran Peck
Format: Article
Language:English
Published: Elsevier 2021-10-01
Subjects:
Performance
SARS-CoV-2
COVID-19
Antibody
Combination
Online Access:http://www.sciencedirect.com/science/article/pii/S1684118221000608
Description
Summary:In an investigation of six anti-SARS-CoV-2 antibody kits with different target antigen and methodology, each kit showed comparable performance. As false-positive reactions occurred independently with different kits, specificity increased to 100% when pairs of kits were used. With three-kit combination, both sensitivity (99.1%) and specificity (100%) increased.
ISSN:1684-1182

Similar Items