Evaluation of six anti-SARS-CoV-2 antibody test kits and practical approaches to optimize the diagnostic performance
In an investigation of six anti-SARS-CoV-2 antibody kits with different target antigen and methodology, each kit showed comparable performance. As false-positive reactions occurred independently with different kits, specificity increased to 100% when pairs of kits were used. With three-kit combinati...
| Published in: | Journal of Microbiology, Immunology and Infection |
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| Main Authors: | , , , , , , , , , |
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021-10-01
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| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1684118221000608 |
| _version_ | 1849321556050706432 |
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| author | Jae-Hoon Ko Eun-Jeong Joo Jin Yang Baek Kyungmin Huh Sun Young Cho Cheol-In Kang Doo Ryeon Chung Yae-Jean Kim Eun-Suk Kang Kyong Ran Peck |
| author_facet | Jae-Hoon Ko Eun-Jeong Joo Jin Yang Baek Kyungmin Huh Sun Young Cho Cheol-In Kang Doo Ryeon Chung Yae-Jean Kim Eun-Suk Kang Kyong Ran Peck |
| author_sort | Jae-Hoon Ko |
| collection | DOAJ |
| container_title | Journal of Microbiology, Immunology and Infection |
| description | In an investigation of six anti-SARS-CoV-2 antibody kits with different target antigen and methodology, each kit showed comparable performance. As false-positive reactions occurred independently with different kits, specificity increased to 100% when pairs of kits were used. With three-kit combination, both sensitivity (99.1%) and specificity (100%) increased. |
| format | Article |
| id | doaj-art-5a856ef9bb6c4de08ab2d44ececa29d8 |
| institution | Directory of Open Access Journals |
| issn | 1684-1182 |
| language | English |
| publishDate | 2021-10-01 |
| publisher | Elsevier |
| record_format | Article |
| spelling | doaj-art-5a856ef9bb6c4de08ab2d44ececa29d82025-09-02T10:37:49ZengElsevierJournal of Microbiology, Immunology and Infection1684-11822021-10-0154598398610.1016/j.jmii.2021.03.008Evaluation of six anti-SARS-CoV-2 antibody test kits and practical approaches to optimize the diagnostic performanceJae-Hoon Ko0Eun-Jeong Joo1Jin Yang Baek2Kyungmin Huh3Sun Young Cho4Cheol-In Kang5Doo Ryeon Chung6Yae-Jean Kim7Eun-Suk Kang8Kyong Ran Peck9Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of KoreaDivision of Infectious Diseases, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of KoreaAsia Pacific Foundation for Infectious Diseases (APFID), Seoul, Republic of KoreaDivision of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of KoreaDivision of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of KoreaDivision of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of KoreaDivision of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of KoreaDivision of Infectious Diseases and Immunodeficiency, Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University, School of Medicine, Seoul, Republic of KoreaDepartment of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; Corresponding author. Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06531, Republic of Korea. Fax: +82 2 3410 2719.Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; Corresponding author. Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Republic of Korea. Fax: +82 2 3410 0064.In an investigation of six anti-SARS-CoV-2 antibody kits with different target antigen and methodology, each kit showed comparable performance. As false-positive reactions occurred independently with different kits, specificity increased to 100% when pairs of kits were used. With three-kit combination, both sensitivity (99.1%) and specificity (100%) increased.http://www.sciencedirect.com/science/article/pii/S1684118221000608PerformanceSARS-CoV-2COVID-19AntibodyCombination |
| spellingShingle | Jae-Hoon Ko Eun-Jeong Joo Jin Yang Baek Kyungmin Huh Sun Young Cho Cheol-In Kang Doo Ryeon Chung Yae-Jean Kim Eun-Suk Kang Kyong Ran Peck Evaluation of six anti-SARS-CoV-2 antibody test kits and practical approaches to optimize the diagnostic performance Performance SARS-CoV-2 COVID-19 Antibody Combination |
| title | Evaluation of six anti-SARS-CoV-2 antibody test kits and practical approaches to optimize the diagnostic performance |
| title_full | Evaluation of six anti-SARS-CoV-2 antibody test kits and practical approaches to optimize the diagnostic performance |
| title_fullStr | Evaluation of six anti-SARS-CoV-2 antibody test kits and practical approaches to optimize the diagnostic performance |
| title_full_unstemmed | Evaluation of six anti-SARS-CoV-2 antibody test kits and practical approaches to optimize the diagnostic performance |
| title_short | Evaluation of six anti-SARS-CoV-2 antibody test kits and practical approaches to optimize the diagnostic performance |
| title_sort | evaluation of six anti sars cov 2 antibody test kits and practical approaches to optimize the diagnostic performance |
| topic | Performance SARS-CoV-2 COVID-19 Antibody Combination |
| url | http://www.sciencedirect.com/science/article/pii/S1684118221000608 |
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