Aluminum Triflate—Catalyzed Adamantylation of N-Nucleophiles

An efficient method is proposed for N-adamantylation of primary carboxamides and sulfonamides, ethyl carbamate, and 4-nitroaniline using the stoichiometric amount of 1-adamantanol in the presence of 5 mol% aluminum triflate in nitromethane. Similarities and differences between adamantylation of some...

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Bibliographic Details
Published in:Proceedings
Main Authors: Valery V. Konshin, Vitaly A. Shcherbinin, Ida A. Lupanova, Dzhamilya N. Konshina
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Subjects:
adamantylation
1-adamantanol
Lewis acid
aluminum triflate
Online Access:http://www.mdpi.com/2504-3900/9/1/21
Description
Summary:An efficient method is proposed for N-adamantylation of primary carboxamides and sulfonamides, ethyl carbamate, and 4-nitroaniline using the stoichiometric amount of 1-adamantanol in the presence of 5 mol% aluminum triflate in nitromethane. Similarities and differences between adamantylation of some azoles catalyzed by aluminum triflate in nitromethane and the reaction catalyzed by Brønsted acids were revealed.
ISSN:2504-3900

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