Characterization of a Mesoporous Silica Nanoparticle Formulation Loaded with Mitomycin C Lipidic Prodrug (MLP) and In Vitro Comparison with a Clinical-Stage Liposomal Formulation of MLP

Nanomedicines have revolutionized the treatment of certain types of cancer, as is the case of doxil, liposomal formulation with doxorubicin encapsulated, in the treatment of certain types of ovarian cancer, AIDS-related Kaposi sarcoma, and multiple myeloma. These nanomedicines can improve the perfor...

Full description

Bibliographic Details
Published in:	Pharmaceutics
Main Authors:	Miguel Manzano, Alberto Gabizón, María Vallet-Regí
Format:	Article
Language:	English
Published:	MDPI AG 2022-07-01
Subjects:	nanomedicines mesoporous silica nanoparticles liposomal formulation
Online Access:	https://www.mdpi.com/1999-4923/14/7/1483

Similar Items

Mesoporous Silica Nanoparticles as Theranostic Antitumoral Nanomedicines
by: Alejandro Baeza, et al.
Published: (2020-10-01)

Mesoporous Silica Nanoparticles for Co-Delivery of Drugs and Nucleic Acids in Oncology: A Review
by: Juan L. Paris, et al.
Published: (2020-06-01)

Encapsulation of Anti-Tuberculosis Drugs within Mesoporous Silica and Intracellular Antibacterial Activities
by: Xin Xia, et al.
Published: (2014-09-01)

Regenerative medicine: Hydrogels and mesoporous silica nanoparticles
by: Jesús L. Pablos, et al.
Published: (2024-12-01)

Formulation and optimization of mesoporous silica loaded gel containing extract of Rosmarinus officinalis for treatment of acute wound healing
by: Raosaheb S. Shendge, et al.
Published: (2024-08-01)

Advances in Mesoporous Silica Nanoparticles: Synthesis, Characterization, and Biomedical Uses
by: Ozi Adi Saputra, et al.
Published: (2024-09-01)

Mesoporous Silica Nanoparticles: Properties and Strategies for Enhancing Clinical Effect
by: Alex N. Frickenstein, et al.
Published: (2021-04-01)

Role of mesoporous silica nanoparticles for the drug delivery applications
by: Baranya Murugan, et al.
Published: (2020-01-01)

Development of new bexarotene-loaded mesoporous silica systems for topical pharmaceutical formulations
by: Aurelia Vasile, et al.
Published: (2018-03-01)

Mesoporous Silica Nanoparticles as Carriers for Therapeutic Biomolecules
by: Rafael R. Castillo, et al.
Published: (2020-05-01)

Fabricating a PDA-Liposome Dual-Film Coated Hollow Mesoporous Silica Nanoplatform for Chemo-Photothermal Synergistic Antitumor Therapy
by: Chuanyong Fan, et al.
Published: (2023-04-01)

Immobilization of Levocetirizine on Mesoporous Silica for Antiallergenic Gel Formulation
by: Klára Szentmihályi, et al.
Published: (2024-10-01)

Bioactive Loaded Novel Nano-Formulations for Targeted Drug Delivery and Their Therapeutic Potential
by: Sapna Kumari, et al.
Published: (2022-05-01)

Influence of the Surface Functionalization on the Fate and Performance of Mesoporous Silica Nanoparticles
by: Miguel Gisbert-Garzarán, et al.
Published: (2020-05-01)

Mesoporous Silica-Based Nanoplatforms Are Theranostic Agents for the Treatment of Inflammatory Disorders
by: Bhagavathi Sundaram Sivamaruthi, et al.
Published: (2023-01-01)

Enteric Coating Enhances the Biopharmaceutical Performance of a Silica–Lipid Formulation of Abiraterone Acetate
by: Ali Taheri, et al.
Published: (2025-10-01)

Mesoporous Silica Nanoparticles for the Treatment of Complex Bone Diseases: Bone Cancer, Bone Infection and Osteoporosis
by: Miguel Gisbert-Garzarán, et al.
Published: (2020-01-01)

Effect of Process Parameters on the critical attributes of the Liposomal formulations
by: Bayan Abu Ras, et al.
Published: (2022-11-01)

Delivery of Therapeutic Biopolymers Employing Silica-Based Nanosystems
by: Zoila Gándara, et al.
Published: (2023-01-01)

Mesoporous silica nanocarriers as drug delivery systems for anti-tubercular agents: a review
by: Josephine Oluwagbemisola Tella, et al.
Published: (2022-06-01)

Physicochemical characterization of a lycopene‐loaded mesoporous silica nanoparticle formulation
by: Gabriela Corrêa Carvalho, et al.
Published: (2024-08-01)

Amine-Impregnated Dendritic Mesoporous Silica for the Adsorption of Formaldehyde
by: Ji Myeong Lee, et al.
Published: (2023-12-01)

Insights into Liposomal and Gel-Based Formulations for Dermatological Treatments
by: Giovanni Strazzabosco, et al.
Published: (2025-03-01)

Redox-Responsive Mesoporous Silica Nanoparticles for Cancer Treatment: Recent Updates
by: Miguel Gisbert-Garzarán, et al.
Published: (2021-08-01)

Synthesis and physicochemical characterization of mesoporous hydroxyapatite and its application in toothpaste formulation
by: Azarmidokht Nikfallah, et al.
Published: (2023-10-01)

Solubility enhancement study of lumefantrine by formulation of liquisolid compact using mesoporous silica as a novel adsorbent
by: Sayani Bhattacharyya, et al.
Published: (2022-12-01)

Novel Methods for Liposome Formulation: Advancements and Innovations
by: Bianca ENARU, et al.
Published: (2023-11-01)

Nanoantibiotics Based in Mesoporous Silica Nanoparticles: New Formulations for Bacterial Infection Treatment
by: Elena Álvarez, et al.
Published: (2021-11-01)

Liposomal Formulations for Nose-to-Brain Delivery: Recent Advances and Future Perspectives
by: Soon-Seok Hong, et al.
Published: (2019-10-01)

Oil absorption in mesoporous silica particles
by: Radislav Filipović, et al.
Published: (2010-12-01)

Liposome-Based Adjuvants for Subunit Vaccines: Formulation Strategies for Subunit Antigens and Immunostimulators
by: Signe Tandrup Schmidt, et al.
Published: (2016-03-01)

Core/shell magnetic mesoporous silica nanoparticles with radially oriented wide mesopores
by: Nikola Ž. Knežević
Published: (2014-06-01)

Synthesis of Two Methotrexate Prodrugs for Optimizing Drug Loading into Liposomes
by: Valentina Di Francesco, et al.
Published: (2021-03-01)

Predicting liposome formulations by the integrated machine learning and molecular modeling approaches
by: Run Han, et al.
Published: (2023-05-01)

An Assessment of Mesoporous Silica Nanoparticle Architectures as Antigen Carriers
by: Xinyue Huang, et al.
Published: (2020-03-01)

Superiority of Mesoporous Silica-Based Amorphous Formulations over Spray-Dried Solid Dispersions
by: Hongwei Zhang, et al.
Published: (2022-02-01)

Formulation and Biological Evaluation of Mesoporous Silica Nanoparticles Loaded with Combinations of Sortase A Inhibitors and Antimicrobial Peptides
by: Sitah Alharthi, et al.
Published: (2022-05-01)

pH-Responsive Mesoporous Silica and Carbon Nanoparticles for Drug Delivery
by: Miguel Gisbert-Garzarán, et al.
Published: (2017-01-01)

Mesoporous Silica Materials as Drug Delivery: “The Nightmare” of Bacterial Infection
by: Marina Martínez-Carmona, et al.
Published: (2018-12-01)

Disordered mesoporous silica particles: an emerging platform to deliver proteins to the lungs
by: Aura Rocío Hernández, et al.
Published: (2024-12-01)