Factors influencing hematological toxicity and adverse effects of perioperative hyperthermic intraperitoneal vs intraperitoneal chemotherapy in gastrointestinal cancer

Intraperitoneal (IP) chemotherapy (IPC), including hyperthermic intraperitoneal chemotherapy (HIPEC), has emerged as a promising approach to control peritoneal metastases in gastrointestinal (GI) cancers. However, the safety profile and toxicity spectrum of IPC remain incompletely understood. This s...

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Bibliographic Details
Published in:Open Medicine
Main Authors: Zhang Xue, Zheng Zhewen, Gao Hui, Yang Ziqi, Bai Jian
Format: Article
Language:English
Published: De Gruyter 2025-08-01
Subjects:
perioperative
hepatotoxicity
intraperitoneal chemotherapy
hipec
gastrointestinal cancer
d-dimer
Online Access:https://doi.org/10.1515/med-2025-1260
Description
Summary:Intraperitoneal (IP) chemotherapy (IPC), including hyperthermic intraperitoneal chemotherapy (HIPEC), has emerged as a promising approach to control peritoneal metastases in gastrointestinal (GI) cancers. However, the safety profile and toxicity spectrum of IPC remain incompletely understood. This study aimed to evaluate the incidence of hematologic and biochemical adverse reactions following surgery with or without IPC and to compare the toxicity profiles of normothermic IPC and HIPEC. Additionally, potential risk factors for liver injury were investigated to guide clinical management.
ISSN:2391-5463

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