Disease-associated metabolic pathways affected by heavy metals and metalloid
Increased exposure to environmental heavy metals and metalloids and their associated toxicities has become a major threat to human health. Hence, the association of these metals and metalloids with chronic, age-related metabolic disorders has gained much interest. The underlying molecular mechanisms...
| الحاوية / القاعدة: | Toxicology Reports |
|---|---|
| المؤلفون الرئيسيون: | , , , |
| التنسيق: | مقال |
| اللغة: | الإنجليزية |
| منشور في: |
Elsevier
2023-01-01
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://www.sciencedirect.com/science/article/pii/S221475002300046X |
| _version_ | 1849321455393701888 |
|---|---|
| author | Zinia Haidar Kaniz Fatema Sabrina Samad Shoily Abu Ashfaqur Sajib |
| author_facet | Zinia Haidar Kaniz Fatema Sabrina Samad Shoily Abu Ashfaqur Sajib |
| author_sort | Zinia Haidar |
| collection | DOAJ |
| container_title | Toxicology Reports |
| description | Increased exposure to environmental heavy metals and metalloids and their associated toxicities has become a major threat to human health. Hence, the association of these metals and metalloids with chronic, age-related metabolic disorders has gained much interest. The underlying molecular mechanisms that mediate these effects are often complex and incompletely understood. In this review, we summarize the currently known disease-associated metabolic and signaling pathways that are altered following different heavy metals and metalloids exposure, alongside a brief summary of the mechanisms of their impacts. The main focus of this study is to explore how these affected pathways are associated with chronic multifactorial diseases including diabetes, cardiovascular diseases, cancer, neurodegeneration, inflammation, and allergic responses upon exposure to arsenic (As), cadmium (Cd), chromium (Cr), iron (Fe), mercury (Hg), nickel (Ni), and vanadium (V). Although there is considerable overlap among the different heavy metals and metalloids-affected cellular pathways, these affect distinct metabolic pathways as well. The common pathways may be explored further to find common targets for treatment of the associated pathologic conditions. |
| format | Article |
| id | doaj-art-5e2d50726aac4e2c84b8cd2f354d7bc6 |
| institution | Directory of Open Access Journals |
| issn | 2214-7500 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| spelling | doaj-art-5e2d50726aac4e2c84b8cd2f354d7bc62025-09-02T11:01:53ZengElsevierToxicology Reports2214-75002023-01-011055457010.1016/j.toxrep.2023.04.010Disease-associated metabolic pathways affected by heavy metals and metalloidZinia Haidar0Kaniz Fatema1Sabrina Samad Shoily2Abu Ashfaqur Sajib3Department of Genetic Engineering & Biotechnology, University of Dhaka, Dhaka 1000, BangladeshDepartment of Genetic Engineering & Biotechnology, University of Dhaka, Dhaka 1000, BangladeshDepartment of Genetic Engineering & Biotechnology, University of Dhaka, Dhaka 1000, BangladeshCorresponding author.; Department of Genetic Engineering & Biotechnology, University of Dhaka, Dhaka 1000, BangladeshIncreased exposure to environmental heavy metals and metalloids and their associated toxicities has become a major threat to human health. Hence, the association of these metals and metalloids with chronic, age-related metabolic disorders has gained much interest. The underlying molecular mechanisms that mediate these effects are often complex and incompletely understood. In this review, we summarize the currently known disease-associated metabolic and signaling pathways that are altered following different heavy metals and metalloids exposure, alongside a brief summary of the mechanisms of their impacts. The main focus of this study is to explore how these affected pathways are associated with chronic multifactorial diseases including diabetes, cardiovascular diseases, cancer, neurodegeneration, inflammation, and allergic responses upon exposure to arsenic (As), cadmium (Cd), chromium (Cr), iron (Fe), mercury (Hg), nickel (Ni), and vanadium (V). Although there is considerable overlap among the different heavy metals and metalloids-affected cellular pathways, these affect distinct metabolic pathways as well. The common pathways may be explored further to find common targets for treatment of the associated pathologic conditions.http://www.sciencedirect.com/science/article/pii/S221475002300046XHeavy metalMetalloidDisease-associated metabolic pathwaysArsenicCadmiumChromium |
| spellingShingle | Zinia Haidar Kaniz Fatema Sabrina Samad Shoily Abu Ashfaqur Sajib Disease-associated metabolic pathways affected by heavy metals and metalloid Heavy metal Metalloid Disease-associated metabolic pathways Arsenic Cadmium Chromium |
| title | Disease-associated metabolic pathways affected by heavy metals and metalloid |
| title_full | Disease-associated metabolic pathways affected by heavy metals and metalloid |
| title_fullStr | Disease-associated metabolic pathways affected by heavy metals and metalloid |
| title_full_unstemmed | Disease-associated metabolic pathways affected by heavy metals and metalloid |
| title_short | Disease-associated metabolic pathways affected by heavy metals and metalloid |
| title_sort | disease associated metabolic pathways affected by heavy metals and metalloid |
| topic | Heavy metal Metalloid Disease-associated metabolic pathways Arsenic Cadmium Chromium |
| url | http://www.sciencedirect.com/science/article/pii/S221475002300046X |
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