Aortic aneurysm as a complication of myeloperoxidase-antineutrophil cytoplasmic antibody-associated vasculitis

• الحاوية / القاعدة: Open Medicine
• المؤلفون الرئيسيون: Satomura Atsushi, Fujita Takayuki, Maruyama Takashi, Hamada Hiroaki, Nozawa Yukinari, Takayama Eiichi, Maruyama Toshiharu, Nakayama Tomohiro
• التنسيق: مقال
• اللغة: الإنجليزية
• منشور في: De Gruyter 2017-12-01
• الموضوعات: antineutrophil cytoplasmic antibody-associated vasculitis (ANCA-associated vasculitis); myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA); microscopic polyangiitis (MPA) aortic aneurysm; connective tissue disease
• الوصول للمادة أونلاين: http://www.degruyter.com/view/j/med.2017.12.issue-1/med-2017-0065/med-2017-0065.xml?format=INT
• تدمد: 2391-5463

Myeloperoxidase-antineutrophil cytoplasmic antibody-associated vasculitis (MPO-AAV) does not usually involve large vessels, such as the aorta. However, we experienced three cases having an aortic aneurysm as a complication of MPO-AAV with renal insufficiency. In one patient it involved the onset of descending aortic dissection during treatment for MPO-AAV; another two patients had an abdominal aortic aneurysm at the time of our diagnosis of MPO-AAV. Although we found no pathological evidence in our patients, MPO-AAV might result in large vessel inflammation. Therefore, we suggest that patients with MPO-AAV should be examined by computed tomography scan to check for the presence of an aortic aneurysm.