| 要約: | Burdock (Arctium lappa) seed oil contains a high concentration of linoleic acid being important for process of skin keratinization and functioning of the skin barrier. The aim of this study was to develop a stable nanoemulsion gel containing burdock seed oil, by using different stabilizers (phospholipid or polysorbate or poloxamer), and to investigate its potential to restore the compromised skin barrier function and reduce erythema. Nanoemulsion gels were investigated for their stability (temperature stress test, centrifugation test, pH value) and in vivo effects on transepidermal water loss (TEWL) and erythema in human skin, and molecular docking analysis was performed for ligands from the oil and the used stabilizers. Obtained results revealed that the chemical constituents, i.e. fatty acids, of burdock seed oil have sufficient compatibility with the used stabilizers in nanoemulsion gels. Tested formulations had a number of appropriate physicochemical characteristics, such as physiological pH, particle size and viscosity, which were suitable for skin care applications. Molecular docking studies revealed that all ligands of burdock oil are highly compatible with lecithin and polysorbate 80, as they show sufficient binding affinity for them, while they are showing somewhat lower binding affinity for poloxamer 407. Application of the gels onto the skin revealed that the nanoemulsion gel stabilized with lecithin led to a significantly greater reduction (p < 0.05) in TEWL compared to the placebo gel and untreated skin, being the best formulation showing great promise for skin healing. Based on these results, formulation with lecithin could be incorporated into cosmetic products such as creams, lotions, and serums, enabling industries to enhance product formulations and offer greater healthcare benefits to consumers.
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