Fc‐gamma receptor polymorphisms, cetuximab therapy, and overall survival in the CCTG CO.20 trial of metastatic colorectal cancer

Abstract Background Two germ line Fc‐γ receptor (FCGR) polymorphisms, rs1801274 [FCGR2A; His(H)131Arg(R)] and rs396991 [FCGR3A; Phe(F)158Val(V)], produce altered proteins through amino acid substitutions. We previously reported that the FCGR2A H/H genotype was associated with longer overall survival...

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:	Cancer Medicine
المؤلفون الرئيسيون:	Daniel Shepshelovich, Amanda R. Townsend, Osvaldo Espin‐Garcia, Lidija Latifovic, Chris J. O’Callaghan, Derek J. Jonker, Dongsheng Tu, Eric Chen, Eric Morgen, Timothy J. Price, Jeremy Shapiro, Lillian L. Siu, Michiaki Kubo, Alexander Dobrovic, Mark J. Ratain, Wei Xu, Taisei Mushiroda, Geoffrey Liu
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	Wiley 2018-11-01
الموضوعات:	cetuximab FCGR2A FCGR3A polymorphism survival
الوصول للمادة أونلاين:	https://doi.org/10.1002/cam4.1819

مواد مشابهة

Single Nucleotide Polymorphism rs10919543 in FCGR2A/FCGR3A Region Confers Susceptibility to Takayasu Arteritis in Chinese Population
حسب: Fang Qin, وآخرون
منشور في: (2016-01-01)

FCGR2/3 polymorphisms are associated with susceptibility to Kawasaki disease but do not predict intravenous immunoglobulin resistance and coronary artery aneurysms
حسب: Paula Uittenbogaard, وآخرون
منشور في: (2024-09-01)

Association of FCGR2A rs1801274 and FCGR3A rs396991 polymorphisms with various autoimmune diseases: a meta-analysis
حسب: Elena Thaler, وآخرون
منشور في: (2025-09-01)

The CD16A and CD16B mRNA level as potential immunological marker in colorectal cancer
حسب: N. V. Krasnogorova, وآخرون
منشور في: (2019-05-01)

FCGR3A V158F gene polymorphism and trastuzumab response in HER2-positive breast cancer patients
حسب: Marwa A. Abdel-Wahed, وآخرون
منشور في: (2024-10-01)

An Engineered Human Fc variant With Exquisite Selectivity for FcγRIIIaV158 Reveals That Ligation of FcγRIIIa Mediates Potent Antibody Dependent Cellular Phagocytosis With GM-CSF-Differentiated Macrophages
حسب: Tae Hyun Kang, وآخرون
منشور في: (2019-03-01)

The Development and Challenge of the CHSN01 Jacket for the CS Magnet in China’s Future Fusion Device
حسب: Yongsheng Wu, وآخرون
منشور في: (2025-05-01)

Combined FCGR2A (131H/R) and FCGR3A (158F/V) genotypes and their gender-specific association with chronic and refractory immune thrombocytopenia in Palestinian children
حسب: Khitam Amer, وآخرون
منشور في: (2025-10-01)

Prognostic significance and gene co-expression network of CD16A and FGL2 in gliomas
حسب: Ziwen Cao, وآخرون
منشور في: (2024-11-01)

Increased levels of a pro-inflammatory IgG receptor in the midbrain of people with schizophrenia
حسب: A. Petty, وآخرون
منشور في: (2022-07-01)

Modeling of clinical phenotypes in systemic lupus erythematosus based on the platelet transcriptome and FCGR2a genotype
حسب: MacIntosh G. Cornwell, وآخرون
منشور في: (2023-04-01)

Illustration of the Distribution of DNA Sequences and Their Frequencies Within the <i>MEP2</i> Gene Across Ten <i>Candida</i> Species
حسب: A. A. Dawood
منشور في: (2024-11-01)

Avelumab induces greater Fc-Fc receptor-dependent natural killer cell activation and dendritic cell crosstalk compared to durvalumab
حسب: Nicole Osborne, وآخرون
منشور في: (2025-12-01)

Impact of FCGR2A rs1801274 and IL-6R rs2228145 polymorphisms on tocilizumab response in the Iranian population with severe COVID-19
حسب: Nastaran Injinari, وآخرون
منشور في: (2024-10-01)

Integrated transcriptomics and proteomics assay identifies the role of FCGR1A in maintaining sperm fertilization capacity during semen cryopreservation in sheep
حسب: Jiachen Bai, وآخرون
منشور في: (2023-08-01)

A Method Utilizing an Image Visibility Graph to Portray the Arrangement of Genomic Data Sequencing, Gene Frequencies for The Peptidoglycan-Associated Lipoprotein (Pal) Gene in Brucella Spp., and Prevalence of Brucellosis in Nineveh
حسب: Ali Adel DAWOOD
منشور في: (2024-06-01)

FCGR2A defines prognostic immune subtypes and drives tumor progression in hepatocellular carcinoma
حسب: Deyuan Zhong, وآخرون
منشور في: (2025-10-01)

Single-cell analysis of peripheral blood and pleural effusion reveals functional diversity of γδ T cells in tuberculosis infection
حسب: Yanjun Feng, وآخرون
منشور في: (2025-06-01)

FCGR1A Alleviates Ischemic Stroke-induced Injury by Promoting Anti-Inflammatory Microglial Polarization via the AMPK–mTOR Signaling Pathway
حسب: Meng Liu, وآخرون
منشور في: (2025-04-01)

Recapitulation of Candidate Systemic Lupus Erythematosus-Associated Variants in Koreans
حسب: Ki-Sung Kwon, وآخرون
منشور في: (2016-09-01)

Machine learning-driven dissection of the obesity-ccRCC interface: FCGR2A emerges as a central coordinator of tumor-immune crosstalk
حسب: Zhongyuan He, وآخرون
منشور في: (2025-10-01)

Integrative Pan-Cancer Analysis Confirmed that FCGR3A is a Candidate Biomarker Associated With Tumor Immunity
حسب: Lilin Li, وآخرون
منشور في: (2022-05-01)

Elk1 enhances inflammatory cell infiltration and exacerbates acute lung injury/acute respiratory distress syndrome by suppressing Fcgr2b transcription
حسب: Shiyou Wei, وآخرون
منشور في: (2024-04-01)

Fc gamma receptor IIb in tumor-associated macrophages and dendritic cells drives poor prognosis of recurrent glioblastoma through immune-associated signaling pathways
حسب: Xiong Jin, وآخرون
منشور في: (2023-01-01)

FcγR Genetic Variation and HIV-1 Vaccine Efficacy: Context And Considerations
حسب: Ria Lassaunière, وآخرون
منشور في: (2021-12-01)

FCGR2A contributes to M2 macrophages polarization in HCC through IL-4/JAK/STAT6 axis
حسب: Shaojun Li, وآخرون
منشور في: (2025-08-01)

Classification and clinical significance of immunogenic cell death-related genes in Plasmodium falciparum infection determined by integrated bioinformatics analysis and machine learning
حسب: Yan-hui Zhang, وآخرون
منشور في: (2024-02-01)

Identification and validation of palmitoylation-related biomarkers in gestational diabetes mellitus
حسب: Kai Zhang, وآخرون
منشور في: (2025-03-01)

Epistatic Interactions Between Mutations of Deoxyribonuclease 1-Like 3 and the Inhibitory Fc Gamma Receptor IIB Result in Very Early and Massive Autoantibodies Against Double-Stranded DNA
حسب: Thomas Weisenburger, وآخرون
منشور في: (2018-07-01)

中国南方地区人群ＦＣＧＲ２Ａ基因多态性与强直性脊柱炎的相关性
منشور في: (2015-01-01)

Anisotropic FCGR behaviour in hot-rolled Mg-3Al-0.5Ce alloy
حسب: Prakash C. Gautam, وآخرون
منشور في: (2024-07-01)

GENETIC POLYMORPHISMS OF CD14, TNFα AND FCGR2A IN THE PATIENTS WITH INFLUENZA A H1N1 IN TRANSBAIKALIA REGION
حسب: V. V. Petrov, وآخرون
منشور في: (2014-07-01)

Single-cell data revealed CD14-type and FCGR3A-type macrophages and relevant prognostic factors for predicting immunotherapy and prognosis in stomach adenocarcinoma
حسب: Mengling Li, وآخرون
منشور في: (2024-01-01)

NK Cytotoxicity Mediated by NK-92 Cell Lines Expressing Combinations of Two Allelic Variants for <i>FCGR3</i>
حسب: Marta Freitas Monteiro, وآخرون
منشور في: (2024-07-01)

Comparative Analysis of <i>FCGR</i> Gene Polymorphism in Pulmonary Sarcoidosis and Tuberculosis
حسب: Marlena Typiak, وآخرون
منشور في: (2023-04-01)

FCGR3A F158V alleles frequency differs in multiple myeloma patients from healthy population
حسب: Michaël Constantinides, وآخرون
منشور في: (2024-12-01)

FCGR2B knockdown alleviates diabetes-induced cognitive dysfunction by altering neuronal excitability
حسب: Yinmeng Qu, وآخرون
منشور في: (2025-06-01)

Comprehensive approach for identification of functional FCGR2C alleles resulting in protein expression as a determinant for predicting predisposition to autoimmunity
حسب: Dorit Lehmann, وآخرون
منشور في: (2021-12-01)

Spatial transcriptomics reveals distinct role of monocytes/macrophages with high FCGR3A expression in kidney transplant rejections
حسب: Yan Chen Wongworawat, وآخرون
منشور في: (2025-09-01)

Effect of Nickel Contents on Fatigue Crack Growth Rate and Fracture Toughness for Nickel Alloy Steels
حسب: Jeong Yeol Park, وآخرون
منشور في: (2022-01-01)