Three-Dimensional-Bioprinted Liver Chips and Challenges

Drug testing, either on animals or on 2D cell cultures, has its limitations due to inaccurate mimicking of human pathophysiology. The liver, as one of the key organs that filters and detoxifies the blood, is susceptible to drug-induced injuries. Integrating 3D bioprinting with microfluidic chips to...

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Bibliographic Details
Published in:Applied Sciences
Main Authors: Sajjad Rahmani Dabbagh, Berin Ozdalgic, Nur Mustafaoglu, Savas Tasoglu
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Subjects:
organ-on-a-chip
liver
bioprinting
tissue-on-a-chip
Online Access:https://www.mdpi.com/2076-3417/12/10/5029
Description
Summary:Drug testing, either on animals or on 2D cell cultures, has its limitations due to inaccurate mimicking of human pathophysiology. The liver, as one of the key organs that filters and detoxifies the blood, is susceptible to drug-induced injuries. Integrating 3D bioprinting with microfluidic chips to fabricate organ-on-chip platforms for 3D liver cell cultures with continuous perfusion can offer a more physiologically relevant liver-mimetic platform for screening drugs and studying liver function. The development of organ-on-chip platforms may ultimately contribute to personalized medicine as well as body-on-chip technology that can test drug responses and organ–organ interactions on a single or linked chip model.
ISSN:2076-3417

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