Aging and immunity: Unraveling the complex relationship

The process of aging is an inherent facet of human existence, entailing various changes within the body, notably in the immune system. This article explores the profound impact of aging on immunity, elucidating its implications for healthcare, disease vulnerability and overall quality of life. Drawi...

Full description

Bibliographic Details
Published in:	AIMS Allergy and Immunology
Main Author:	Arosh S. Perera Molligoda Arachchige
Format:	Article
Language:	English
Published:	AIMS Press 2023-08-01
Subjects:	immunosenescence inflammaging aging immunity vaccination gut microbiota
Online Access:	https://www.aimspress.com/article/doi/10.3934/Allergy.2023015

Similar Items

The Interplay between Immunosenescence and Microbiota in the Efficacy of Vaccines
by: Rossella Cianci, et al.
Published: (2020-11-01)

The immune system through the ages
by: Ken S. Rosenthal, et al.
Published: (2022-09-01)

The Impact of Immune System Aging on Infectious Diseases
by: Eugenia Quiros-Roldan, et al.
Published: (2024-04-01)

Adaptive immunity and atherosclerosis: aging at its crossroads
by: Roy P. M. Snijckers, et al.
Published: (2024-04-01)

Interconnections between Inflammageing and Immunosenescence during Ageing
by: Thibault Teissier, et al.
Published: (2022-01-01)

Immune Aging, Immunosenescence, and Inflammaging: Implications for Vaccine Response in Older Adults
by: Shahab Falahi, et al.
Published: (2025-07-01)

Aging and serum MCP-1 are associated with gut microbiome composition in a murine model
by: Melissa N. Conley, et al.
Published: (2016-03-01)

Osteoarthritis and age. Role of aging in the etiology and pathogenesis of the disease
by: L. V. Luchikhina, et al.
Published: (2017-03-01)

Biomarkers of the ageing immune system and their association with frailty – A systematic review
by: E. Tran Van Hoi, et al.
Published: (2023-06-01)

Impact of immunosenescence and inflammaging on the effects of immune checkpoint inhibitors
by: Chuandong Hou, et al.
Published: (2024-01-01)

Elderly individuals exhibit dysregulated monocyte responses to viral immune complexes compared to adults and children
by: Léa Domitien Payet, et al.
Published: (2025-08-01)

The 3 I’s of immunity and aging: immunosenescence, inflammaging, and immune resilience
by: Marianna V. Wrona, et al.
Published: (2024-10-01)

Immune cell phenotypes and mortality in the Framingham Heart Study
by: Ahmed A. Y. Ragab, et al.
Published: (2024-06-01)

GROWTH HORMONE, IMMUNOSENESCENCE AND VACCINATION FAILURE IN THE ELDERLY
by: José E Belizário, et al.
Published: (2023-12-01)

The diseased kidney: aging and senescent immunology
by: Mingxuan Chi, et al.
Published: (2022-11-01)

Age-related changes in the immune system and challenges for the development of age-specific vaccines
by: T. Mark Doherty, et al.
Published: (2025-12-01)

Understanding the Complex Dynamics of Immunosenescence in Multiple Sclerosis: From Pathogenesis to Treatment
by: Monica Neațu, et al.
Published: (2024-08-01)

Parallels in Immunometabolic Adipose Tissue Dysfunction with Ageing and Obesity
by: William Trim, et al.
Published: (2018-02-01)

Manifesto on the Value of Adult Immunization: “We Know, We Intend, We Advocate”
by: Raffaele Antonelli-Incalzi, et al.
Published: (2021-10-01)

Fasting and calorie restriction modulate age‐associated immunosenescence and inflammaging
by: Anteneh Mehari Tizazu
Published: (2024-08-01)

Physiological Basis of Immune Function Among Geriatric Population and Nutrition: A Narrative Review
by: Abhay Sai, et al.
Published: (2025-09-01)

Zinc deficiency as possible link between immunosenescence and age-related diseases
by: Michael Tobias Schulz, et al.
Published: (2025-05-01)

Aging brain: exploring the interplay between bone marrow aging, immunosenescence, and neuroinflammation
by: Ludmila Müller, et al.
Published: (2024-04-01)

Donor and Recipient Age-Mismatches: The Potential of Transferring Senescence
by: Jasper Iske, et al.
Published: (2021-04-01)

Healthy and premature aging of monocytes and macrophages
by: Syamantak Basu, et al.
Published: (2025-03-01)

Immunity in the Progeroid Model of Cockayne Syndrome: Biomarkers of Pathological Aging
by: Khouloud Zayoud, et al.
Published: (2024-02-01)

Increased levels of GM-CSF and CXCL10 and low CD8+ memory stem T Cell count are markers of immunosenescence and severe COVID-19 in older people
by: Johanne Poisson, et al.
Published: (2024-05-01)

Exploring age-related influences on COVID-19 severity and therapeutic approaches for older patients
by: Shafaat Hossain, et al.
Published: (2025-09-01)

Senescent cell-derived extracellular vesicles as potential mediators of innate immunosenescence and inflammaging
by: Shaun Hanley, et al.
Published: (2024-03-01)

Morphofunctional changes of microglia in adult and old Wistar rats
by: A. V. Sentyabreva, et al.
Published: (2023-06-01)

Investigating population-level immunosenescence: From bench to bedside
by: Lucas Leite Cunha, et al.
Published: (2022-08-01)

Cochlear inflammaging: cellular and molecular players of the innate and adaptive immune system in age-related hearing loss
by: Shailee Parekh, et al.
Published: (2023-11-01)

Aging-dependent immunological changes in multiple sclerosis
by: Andrea Iribarren-López, et al.
Published: (2025-10-01)

Immunoinflammation and post-translational modifications in the aging process
by: Jiaqi Xiao, et al.
Published: (2025-08-01)

The Dynamics of B Cell Aging in Health and Disease
by: Jill de Mol, et al.
Published: (2021-10-01)

Aging and chronic inflammation: highlights from a multidisciplinary workshop
by: Danay Saavedra, et al.
Published: (2023-06-01)

Concentrations of urinary neopterin, but not suPAR, positively correlate with age in rhesus macaques
by: Eve B. Cooper, et al.
Published: (2022-10-01)

Respiratory Syncytial Virus Vaccines: Analysis of Pre-Marketing Clinical Trials for Immunogenicity in the Population over 50 Years of Age
by: Georgios Papazisis, et al.
Published: (2024-03-01)

Regulatory RNAs in immunosenescence
by: Atefe Ghamar Talepoor, et al.
Published: (2024-03-01)

Effects of a 6 Week Low-Dose Combined Resistance and Endurance Training on T Cells and Systemic Inflammation in the Elderly
by: Michael Despeghel, et al.
Published: (2021-04-01)