The Distinct Role of HIF-1α and HIF-2α in Hypoxia and Angiogenesis

Hypoxia results in a wide range of adaptive physiological responses, including metabolic reprogramming, erythropoiesis, and angiogenesis. The response to hypoxia at the cellular level is mainly regulated by hypoxia-inducible factors (HIFs): HIF1α and HIF2α isoforms. Although structurally similar and...

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Bibliographic Details
Published in:	Cells
Main Authors:	Mouayad Zuheir Bakleh, Ayman Al Haj Zen
Format:	Article
Language:	English
Published:	MDPI AG 2025-05-01
Subjects:	hypoxia HIF signaling HIF switch angiogenesis
Online Access:	https://www.mdpi.com/2073-4409/14/9/673

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