Scientific reports concerning the impact of interleukin 4, interleukin 10 and transforming growth factor  on cancer cells

• Published in: Central European Journal of Immunology
• Main Authors: Konrad Kwaśniak, Justyna Czarnik-Kwaśniak, Aleksandra Maziarz, David Aebisher, Kinga Zielińska, Bożenna Karczmarek-Borowska, Jacek Tabarkiewicz
• Format: Article
• Language: English
• Published: Termedia Publishing House 2019-07-01
• Subjects: cancer; anti-inflammatory cytokines; il-10; il-4; tgf-
• Online Access: https://www.termedia.pl/Scientific-reports-concerning-the-impact-of-interleukin-4-interleukin-10-and-transforming-growth-factor-on-cancer-cells,10,32984,1,1.html

Cytokines are signalling proteins generated in most part by immune cells that have critical functions in cellular lifespan. Here we present recent data on three selected anti-inflammatory cytokines: interleukin (IL)-10, IL-4 and transforming growth factor  (TGF-). IL-10 inhibits the synthesis of major pro-inflammatory cytokines, chemokines, and mediates anti-inflammatory reactions. IL-4 is a multifunctional cytokine which plays a crucial role in the regulation of immune responses and is involved in processes associated with development and differentiation of lymphocytes and regulation of T cell survival. Transforming TGF-, which in normal cells or pre-cancerous cells, promotes proliferation arrest which represses tumour growth. In this review, we focus on the influence of IL-10, IL-4 and TGF- on various types of cancer as well as potential of these selected cytokines to serve as new biomarkers which can support effective therapies for cancer patients. This article is presented based on a review of the newest research results.