Inhibition of Mitochondrial Complex Function—The Hepatotoxicity Mechanism of Emodin Based on Quantitative Proteomic Analyses

Emodin is the main component of traditional Chinese medicines including rhubarb, <i>Polygonum multiflorum</i>, and <i>Polygonum cuspidatum</i>. It has confirmed hepatotoxicity and may be the main causative agent of liver damage associated with the above-mentioned traditional...

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:	Cells
المؤلفون الرئيسيون:	Longfei Lin, Yuling Liu, Sai Fu, Changhai Qu, Hui Li, Jian Ni
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	MDPI AG 2019-03-01
الموضوعات:	emodin hepatotoxicity proteomic mitochondrial complex
الوصول للمادة أونلاين:	https://www.mdpi.com/2073-4409/8/3/263

مواد مشابهة

Advances in the mechanism of emodin-induced hepatotoxicity
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منشور في: (2024-07-01)

Emodin, an Emerging Mycotoxin, Induces Endoplasmic Reticulum Stress-Related Hepatotoxicity through IRE1α–XBP1 Axis in HepG2 Cells
حسب: Su Been Park, وآخرون
منشور في: (2023-07-01)

Study on the Hepatotoxicity of Emodin and Its Application in the Treatment of Liver Fibrosis
حسب: Yurou Guo, وآخرون
منشور في: (2024-10-01)

Investigating the Mechanism of Emodin in Rheumatoid Arthritis Through the HIF-1α/NLRP3 Pathway and Mitochondrial Autophagy
حسب: Dehao Du, وآخرون
منشور في: (2025-06-01)

Emodin Inhibited Pathological Cardiac Hypertrophy in Response to Angiotensin-Induced Hypertension and Altered the Gut Microbiome
حسب: Levi Evans, وآخرون
منشور في: (2023-08-01)

Reversible Valproate Hepatotoxicity and Associated Mitochondrial Disease
حسب: J Gordon Millichap
منشور في: (2008-02-01)

Inflammatory Stress Potentiates Emodin-Induced Liver Injury in Rats
حسب: Can eTu, وآخرون
منشور في: (2015-10-01)

Emodin and aloe-emodin, two potential molecules in regulating cell migration of skin cells through the MAP kinase pathway and affecting Caenorhabditis elegans thermotolerance
حسب: Aysenur Gunaydin-Akyildiz, وآخرون
منشور في: (2023-07-01)

Emodin as an Inhibitor of PRV Infection In Vitro and In Vivo
حسب: Xiaojing Cai, وآخرون
منشور في: (2023-09-01)

Antiviral Activities of Halogenated Emodin Derivatives against Human Coronavirus NL63
حسب: Monika Horvat, وآخرون
منشور في: (2021-11-01)

Emodin inhibits bladder inflammation and fibrosis in mice with interstitial cystitis by regulating JMJD3
حسب: Junyu Lai, وآخرون
منشور في: (2023-12-01)

Emodin improves renal fibrosis in chronic kidney disease by regulating mitochondrial homeostasis through the mediation of peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (PGC-1α)
حسب: Liuchang Feng, وآخرون
منشور في: (2024-05-01)

Emodin-induced autophagy against cell apoptosis through the PI3K/AKT/mTOR pathway in human hepatocytes
حسب: Zheng X, وآخرون
منشور في: (2019-09-01)

RETRACTED ARTICLE: Emodin enhances osteogenesis and inhibits adipogenesis
حسب: Feng Yang, وآخرون
منشور في: (2014-02-01)

Neuroprotection of Emodin by Inhibition of Microglial NLRP3 Inflammasome-Mediated Pyroptosis
حسب: Wen Jiang, وآخرون
منشور في: (2023-03-01)

Aloe-emodin exhibits growth-suppressive effects on androgen-independent human prostate cancer DU145 cells via inhibiting the Wnt/β-catenin signaling pathway: an in vitro and in silico study
حسب: Talib Hussain, وآخرون
منشور في: (2024-01-01)

A Proteomics Study on the Mechanism of Nutmeg-Induced Hepatotoxicity
حسب: Wei Xia, وآخرون
منشور في: (2021-03-01)

Emodin in cardiovascular disease: The role and therapeutic potential
حسب: Yuanyuan Guo, وآخرون
منشور في: (2022-12-01)

Emodin regulates neutrophil phenotypes to prevent hypercoagulation and lung carcinogenesis
حسب: Zibo Li, وآخرون
منشور في: (2019-03-01)

Anticancer action of naturally occurring emodin for the controlling of cervical cancer
حسب: Priyanka S. Lande, وآخرون
منشور في: (2023-08-01)

Antibiofilm efficacy of emodin alone or combined with ampicillin against methicillin-resistant Staphylococcus aureus
حسب: Maoying Zhao, وآخرون
منشور في: (2025-07-01)

The interaction between self – assembling peptides and emodin and the controlled release of emodin from in-situ hydrogel
حسب: Weipeng Wei, وآخرون
منشور في: (2019-12-01)

Emodin induces apoptosis and autophagy of fibroblasts obtained from patient with ankylosing spondylitis
حسب: Ma C, وآخرون
منشور في: (2019-02-01)

Inhibitory effect of emodin on MRSA biofilm and its mechanism
حسب: LIU Jingyi, وآخرون
منشور في: (2022-04-01)

Response Surface Methodology (RSM)-Based Optimization of Ultrasound-Assisted Extraction of Sennoside A, Sennoside B, Aloe-Emodin, Emodin, and Chrysophanol from <i>Senna alexandrina</i> (Aerial Parts): HPLC-UV and Antioxidant Analysis
حسب: Perwez Alam, وآخرون
منشور في: (2022-01-01)

Emodin inhibits respiratory syncytial virus entry by interactions with fusion protein
حسب: Yingcai Xiong, وآخرون
منشور في: (2024-05-01)

Emodin inhibits colon cancer by altering BCL-2 family proteins and cell survival pathways
حسب: Ian T. Saunders, وآخرون
منشور في: (2019-04-01)

Comparative Proteomic Analysis Shows an Elevation of Mdh1 Associated with Hepatotoxicity Induced by Copper Nanoparticle in Rats
حسب: Shu-wei DONG, وآخرون
منشور في: (2014-05-01)

Screening of a natural compound library identifies emodin, a natural compound from Rheum palmatum Linn that inhibits DPP4
حسب: Zhaokai Wang, وآخرون
منشور في: (2017-05-01)

The Application of Emodin Treatment on Nasopharyngeal Carcinoma Therapy
حسب: Chung-Chun Wu, وآخرون
منشور في: (2024-02-01)

Potential preventative impact of aloe-emodin nanoparticles on cerebral stroke-associated myocardial injury by targeting myeloperoxidase: In supporting with In silico and In vivo studies
حسب: Praveen Kumar Pasala, وآخرون
منشور في: (2024-06-01)

Exploring the Role of β-Sitosterol, Genistein, and Emodin in Periodontal Regeneration
حسب: Prabhu M. Natarajan, وآخرون
منشور في: (2024-12-01)

Progress on the mechanism of action of emodin against breast cancer cells
حسب: Ruoqing Chen, وآخرون
منشور في: (2024-11-01)

Emodin Retarded Renal Fibrosis Through Regulating HGF and TGFβ–Smad Signaling Pathway
حسب: Yang F, وآخرون
منشور في: (2020-09-01)

Inhibition of Epstein-Barr Virus Lytic Cycle by an Ethyl Acetate Subfraction Separated from Polygonum cuspidatum Root and Its Major Component, Emodin
حسب: Ching-Yi Yiu, وآخرون
منشور في: (2014-01-01)

Role of emodin to prevent gastrointestinal cancers: recent trends and future prospective
حسب: Falak Thakral, وآخرون
منشور في: (2025-04-01)

Effect of Ultrasound Treatment on Structural and Physicochemical Properties of Emodin-Casein Complexes
حسب: Chengli LIU, وآخرون
منشور في: (2024-03-01)

Identification of Decrease in TRiC Proteins as Novel Targets of Alpha-Amanitin-Derived Hepatotoxicity by Comparative Proteomic Analysis In Vitro
حسب: Doeun Kim, وآخرون
منشور في: (2021-03-01)

Screening Emodin Derivatives as DPP-4 Inhibitor Candidates: In Silico and In Vitro Assessment
حسب: Dina Azkiyah, وآخرون
منشور في: (2025-05-01)

Emodin promotes the recovery of rheumatoid arthritis by regulating the crosstalk between macrophage subsets and synovial fibroblast subsets
حسب: Lianying Cheng, وآخرون
منشور في: (2025-01-01)