| Summary: | Abstract Background Families of young and middle-aged lymphoma patients face significant burdens affecting their overall functioning and well-being. Caregivers play a critical role in managing these challenges, yet the factors that enhance their ability to support their families effectively, such as caregiver resourcefulness, remain inadequately understood. Aims This study aimed to explore the relationships between caregiver resourcefulness and family functioning, focusing on the mediating roles of family coping and perceived social support. Methods This cross-sectional study was conducted in the oncology units of two tertiary hospitals in China from May to November 2022. Data were collected on caregiver resourcefulness, family coping, perceived social support, and family functioning, and were analyzed using parallel mediation techniques. Results The study included 211 caregivers. Those with higher levels of resourcefulness demonstrated better family functioning. Mediation analysis revealed that family coping and perceived social support partially mediated these relationships (β = − 0.132, 95% CI [−0.208, − 0.063]; β = − 0.123, 95% CI [−0.200, − 0.054], respectively). Both factors jointly mediated the relationships between resourcefulness and the communication and general functioning dimensions. However, neither significantly mediated the relationship between resourcefulness and behavioral control. Conclusions Family coping and perceived social support act as partial parallel mediators in the relationship between caregiver resourcefulness and family functioning. Caregivers who exhibit higher resourcefulness, stronger family coping, and greater perceived social support experience enhanced family functioning, particularly in communication and general functioning domains. These findings highlight the importance of contextual factors, indicating that interventions designed to boost caregiver resourcefulness while promoting effective family coping and support systems are essential for improving outcomes for families navigating the challenges of lymphoma. Clinical trial number Not applicable.
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