Study on the mechanism by which Xuanfu Hua Tang increases sensitivity of hepatocellular carcinoma cells to sorafenib by antagonizing the Notch1 pathway through HIF-2α

BackgroundIt is crucial to explore ways to increase the sensitivity of hepatocellular carcinoma cells to sorafenib.MethodsThe HepG2 and Huh7 cell lines with overexpressed HIF-2α were constructed. The cells were treated with Xuanfu Hua Tang (Xuanfu HT) containing serum and sorafenib separately and by...

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Bibliographic Details
Published in:	Frontiers in Oncology
Main Authors:	Wenzhao Luo, Xian Li, Yiwan Shang, Zhen Chen, Yinglin Cui
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-05-01
Subjects:	Xuanfu Hua hepatocellular carcinoma sorafenib NOTCH1 FOXP3
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2025.1552480/full

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