Effect of a polyherbal immunomodulator on the immunogenicity of booster dose of FMD and FMD-HS-BQ vaccines in dairy cattle

• Published in: Indian Journal of Animal Sciences
• Main Authors: NIDHI MISHRA, RASHMI SINGH, RAJNEESH SIROHI, BHASKAR GANGULY, SHREYA GUPTA, AKHIL KUMAR GUPTA
• Format: Article
• Language: English
• Published: Indian Council of Agricultural Research 2025-02-01
• Subjects: Cattle, Combined vaccine, Dairy, FMD, HS, Monovac, Polyherbal immunomodulator
• Online Access: https://epubs.icar.org.in/index.php/IJAnS/article/view/151036
• ISSN: 0367-8318; 2394-3327

A polyherbal immunomodulator (restobal) was fed orally in dairy cattle (treatment group) to study its effect on the immunogenicity of booster dose of FMD and FMD-HS-BQ vaccines. Serum antibody titres for all three FMD virus serotypes were protective (1.80 log10 to 2.40 log10) in treatment and control groups of vaccinated animals till 90 days of vaccination. Antibody titre did not differ significantly in control and treatment groups. Antibody titres ranging from 1.74 log10 to 1.92 log10 were observed for P. multocida and animals were protected on 90 days of vaccination in both control and treatment groups. The Restobal treated group was no different than the control group in antibody response to FMDV and P. multocida. Antibody response for FMDV was similar with FMD vaccine and FMD-HS-BQ vaccine.