Design, synthesis, and biological investigation of selective human carbonic anhydrase II, IX, and XII inhibitors using 7-aryl/heteroaryl triazolopyrimidines bearing a sulfanilamide scaffold

A novel library of human carbonic anhydrase (hCA) inhibitors based on the 2-sulfanilamido[1,2,4]triazolo[1,5-a]pyrimidine skeleton modified at its 7-position was prepared by an efficient convergent procedure. These derivatives were evaluated in vitro for their inhibition properties against a represe...

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Bibliographic Details
Published in:	Journal of Enzyme Inhibition and Medicinal Chemistry
Main Authors:	Romeo Romagnoli, Tiziano De Ventura, Stefano Manfredini, Erika Baldini, Claudiu T. Supuran, Alessio Nocentini, Andrea Brancale, Carmine Varricchio, Roberta Bortolozzi, Lorenzo Manfreda, Giampietro Viola
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2023-12-01
Subjects:	Carbonic anhydrase inhibitors sulphanilamide antiproliferative activity [1,2,4]triazolo[15-a]pyrimidine structure–activity relationship
Online Access:	https://www.tandfonline.com/doi/10.1080/14756366.2023.2270180

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