CREB–KIF1A–CGRP-positive feedback loop drives central sensitization in chronic migraine

Abstract Background Chronic migraine (CM), defined as ≥ 15 monthly headache days and often involving central sensitization, is a complex neurological disorder. While calcitonin gene-related peptide (CGRP) is a key migraine target, its upstream regulation remains unclear. Kinesin family member 1A (KI...

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Bibliographic Details
Published in:	The Journal of Headache and Pain
Main Authors:	Wei Jiang, Peng Yu, Yan-Min Shi, Li-Xi Zhang, Meng-Tan Cai, Yu Yang, Ming Dong
Format:	Article
Language:	English
Published:	BMC 2025-09-01
Subjects:	Migraine Central sensitization KIF1A CREB Positive feedback loop
Online Access:	https://doi.org/10.1186/s10194-025-02147-4

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