Progress of vimentin in hepatocellular carcinoma

Epithelial-mesenchymal transition (EMT) is a critical mechanism related to invasion, metastasis and drug resistance. Vimentin(VIM), as the biomarker of EMT, functions in regulating EMT and forms epithelial-like cancer stem cells and itself methylation, and exosomes excrete VIM directly or indirectly...

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Bibliographic Details
Published in:Jichu yixue yu linchuang
Main Author: DONG Bao-long, HAN Cai-wen, SHI Ming, ZHENG Wen-xue, YANG Xiao-jun
Format: Article
Language:Chinese
Published: Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. 2020-02-01
Subjects:
vimentin|cancer stem cells|vim methylation|exosomes
Online Access:http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/a190982.pdf
Description
Summary:Epithelial-mesenchymal transition (EMT) is a critical mechanism related to invasion, metastasis and drug resistance. Vimentin(VIM), as the biomarker of EMT, functions in regulating EMT and forms epithelial-like cancer stem cells and itself methylation, and exosomes excrete VIM directly or indirectly, which leads to invasiveness and proliferation, chemotherapy resistance and postoperative recurrence of HCC. Importantly, combine detection of circulating VIM and AFP level in patients' serum samples, significantly improved the sensitivity and specificity for diagnosis of HCC, and predict poor prognosis.
ISSN:1001-6325

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