Synthesis and in vitro Anti-Bacterial Activity of 2-(5-Nitro-2-heteroaryl)-1,3,4-Thiadiazole Derivatives

A new series of 2-(5-nitro-2-heteroaryl)-1,3,4-thiadiazole derivatives, including nitro furan, nitro thiophene and nitro imidazole, were synthesized and screened in vitro for their inhibitory activity against eight bacterial strains. The results showed that most of the synthesized compounds were act...

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Bibliographic Details
Published in:Journal of Sciences, Islamic Republic of Iran
Main Authors: M. Yazdanian, B Zihayat, MH Moshafi, A Khodadadi, A Peimani, A Shamsaddini, M Nourhashemi, Alireza Foroumadi
Format: Article
Language:English
Published: University of Tehran 2020-04-01
Subjects:
1,3,4-thiadiazole
antibacterial activity
synthesis
Online Access:https://jsciences.ut.ac.ir/article_74789_4ef3a45675e366fcbdf240d9dd9c8cbd.pdf
Description
Summary:A new series of 2-(5-nitro-2-heteroaryl)-1,3,4-thiadiazole derivatives, including nitro furan, nitro thiophene and nitro imidazole, were synthesized and screened in vitro for their inhibitory activity against eight bacterial strains. The results showed that most of the synthesized compounds were active against Gram-positive bacteria, determined by MIC method. Among them, compounds 6a, 6b and 6d exhibited strong anti-bacterial effects against the Gram-positive bacteria. The oxidation of synthesized compounds to sulfinyl and sulfonyl bearing analogues did not improve the activity.
ISSN:1016-1104
2345-6914

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